A04 | Expansion of the biofabrication window using 2.5D scaffolds made from (AB)n-segmented copolymers

The aim of the project is the expansion of the biofabrication window of bioinks. By using 2.5D scaffolds – a structurally stable substrate – for the bioprinting process a better precision and reproducibility of the bioink depostion can be achieved. For this purpose, new (AB)n-segmented copolymers with hydrophilic soft segments and supramolecular hard segments are developed, which can be processed by Melt Electrospinning Writing. By selective swelling with biological media hydrogel scaffolds are formed covering a wide range of Young’s Moduli and enabling different cellular interactions. Until today, this cannot be realized with conventional biofabrication processes.

Prof. Dr. Hans-Werner Schmidt
Prof. Dr. Paul Dalton

Ezgi Bakirci

Previous academic education: Yildiz Technical University-Bioengineering, Sabanci University- Material Sciences and Engineering 
Academic Advisor within SFB TRR225: Prof. Dr. Paul Dalton
Subproject: Ultra-soft matrix composite for 3D Neuroglia in vitro Research
Location: University of Würzburg, Department for Functional Materials in Medicine and Dentistry
Topic of thesis: Developing in vitro Culture System for Nerve Tissue Engineering Application using Melt Electrospinning Writing
Main techniques and methodologies to be used: Melt Electrospinning Writing, Hydrogel, Cell Culture

Contact: ezgi.bakirci@fmz.uni-wuerzburg.de

Concratulations to Ezgi Bakirci and Paul Dalton Project A04 & B01. Ezgi Bakirci won the IOP Biofabrication Best Presentation Award 2018 at the @utrechtsummer course 3D Printing & Biofabrication.

Andreas Frank

Previous academic education: Master-Thesis: “Hydrogel gradients based on polyacrylamide”
Academic Advisor within SFB TRR225:  Prof. Hans-Werner Schmidt
Location: University of Bayreuth, Department for Macromolecular Chemistry I
Topic of thesis: Tailored polymers for the biofabrication
Main techniques and methodologies to be used: NMR-spectroscopy, Fourier Transform Infrared Spectroscopy (FT-IR), Size Exclusion Chromato-graphy (SEC), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Dynamic Mechanical Thermal Analysis (DMTA), Rheology, Melt Electrospinning Writing  (MEW), Environmental Scanning Electron Microscopy (ESEMTM)

Contact: andreas.frank@uni-bayreuth.de

Jannik Mechau

Previous academic education: Master Thesis: “Synthesis of Model compounds for donor-acceptor systems in polymer solar cells” (Georg-August Universität Göttingen)
Academic Advisor within SFB TRR225: Prof. Hans-Werner Schmidt
Location: University of Bayreuth, Department for Macromolecular Chemistry I
Topic of thesis: Synthesis and properties of polyethylene glycol containing (AB)n segmented copolymers
Main techniques and methodologies to be used: Polymer synthesis, NMR-spectroscopy, Fourier Transform Infrared Spectroscopy (FT-IR), Size Exclusion Chromatpography (SEC), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Dynamic Mechanical Thermal Analysis (DMTA), Rheology, Melt Electro-spinning Writing (MEW) in cooperation with FMZ Würzburg (Group of Paul Dalton)

Contact: Jannik.Mechau@uni-bayreuth.de

Mechau J, Frank A, Böhm C, Giesa R, Dalton PD, Schmidt HW (2018) Melt Electrowriting of water-swelling (AB)n segmented block copolymers, Annual Conference of the International Society for Biofabrication (ISBF), 28 – 31 October, 2018 (Würzburg, Germany).