Ultra-soft matrices are challenging for cell culture due to their poor structural properties. However, it is known that they promote excellent interconnection between neurons and create neural networks. This project proposes to use highly resolved 3D-printed structures to mechanically stabilize ultra-soft matrices so that 3D electrophysiology can be performed on neural networks. In line with neural networks, controlled migration of glioblastoma tumor cells through similar ultra-soft matrix/fiber composites will also be investigated so that neurons, astrocytes and tumor cells can be used in the future as an in vitro model for glioblastoma research.
Wieland A, Janzen D, Bakirci E, Schäfer N, Strissel PL, Strick R, Villmann C, Dalton P (2018) Ultra-soft Matrix Composites for 3D Neuroglia in vitro Research, Summer School “3D Printing Technologies”, 16 – 20 Jul 2018 (Würzburg, Germany)