C04 | Biofabrication of cellularized and by the AV loop vascularized tissue container for the transplantation of cells producing therapeutic proteins
Principle aim of the project is the development of a transplantable tissue container which enables the in vivo production of recombinant therapeutic proteins for the treatment of autoimmune diseases and cancer. As a model biological TNFR2-Fc is used which corresponds to the clinically approved TNF-blocker Enbrel®.
In the first funding period bioinks supplemented with TNFR2-Fc producer cells have been developed, which will now be used to print structured containers or container inlets enabling accelerated in vivo vascularization. This should allow durable and stable biological production and release in vivo. The effectiveness of the therapeutic tissue container will be assessed in the pristan induced rat arthritis model.