C04 | Biofabrication of cellularized and by the AV loop vascularized tissue container for the transplantation of cells producing therapeutic proteins
The primary goal of project C04 is the development of a transplantable therapeutic container for the in vivo production and release of recombinant proteins. This container consists of an inert shell with a biofabricated matrix enabling the growth of a biologic-secreting cell line. The long-term survival of the producing cells, and thus the continuous secretion of the biologic and its transport into the bloodstream, is achieved through in vivo vascularization via an arteriovenous (AV) loop. The applicability of the therapeutic tissue container will be assessed in project C04 in a rat breast cancer model with a TRAIL death receptor-agonist producing tissue container.
