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C03 | Analysis of tumor dormancy and progression in biofabricated vascularized 3D models

The aim of the second funding period is the in vitro biofabrication of in vivo tumor models as well as in vivo evaluation of tumor models in the vascularized AV loop model. The primary focus will be the evaluation of tumor dormancy and progression and the influence of the tumor microenvironment. Based on our previous studies, more complex tumor models will be biofabricated using different areas, stiffnesses and cell types and the tumor cell behavior will be analyzed also on molecular level.

Prof. Dr. Andreas Arkudas
Prof. Dr. Anja Boßerhoff
PD Dr. Annika Kengelbach-Weigand

Evelin Sandor

Previous academic education: Master of Biology/ Molecularbiology, Immunobiology, Microbiology
Academic Advisor within SFB TRR225: Prof. Dr. Andreas Arkudas, PD Dr. Annika Kengelbach-Weigand
Location: University Hospital of Erlangen, Department of Plastic and Hand Surgery
Topic of thesis: Analysis of tumor dormancy and progression in biofabricated vascularized 3D models
Main techniques and methodologies to be used: cell culture, cell culture assays, (live cell)microscopy, in vivo AV loop, in vivo 3D imaging (Immuno)histology

Contact: Evelin.Sandor@uk-erlangen.de 

Carolin Eckert

Previous academic education: Dual Degree M. Sc. Molecular Sciene / M. Sc. Medicinal Chemistry FAU Erlangen-Nürnberg / University of Wollongong
Academic Advisor within SFB TRR225: Prof. Dr. Anja Bosserhoff
Location: FAU Erlangen-Nürnberg, Department for Biochemistry and Molecular Medicine
Topic of thesis: Analysis of tumor dormancy and progression in biofabricated and in vivo vascularized 3D models
Main techniques and methodologies to be used: Analysis of cell behavior & signaling pathways (cell culture, fluorescence microscopy, bio printing, qPCR, Western Blot, …)

Contact: carolin.eckert@fau.de

Tannaz Karimi

Previous academic education: Master of Biomedical Engineering/ Biomaterials
Academic Advisor within SFB TRR225: PD Dr. Annika Kengelbach-Weigand, Prof. Dr. Andreas Arkudas, Prof. Dr. Anja Bosserhoff,
Location: University Hospital of Erlangen, Department of Plastic and Hand Surgery
Topic of thesis: Analysis of tumor dormancy and progression in biofabricated vascularized 3D models
Main techniques and methodologies to be used: cell culture, cell culture assays, (live cell) microscopy, in vivo AV loop, in vivo 3D imaging (Immuno)histology

Contact: Tannaz.Karimi@uk-erlangen.de

 

2024

Antonelli Y, Krüger R, Buehler A, Monavari M, Fuentes-Chandía M, Colombo F, Palmisano R, Boßerhoff AK, Kappelmann-Fenzl M, Schödel J, Boccaccini AR, Selhuber-Unkel C, Letort G, Leal-Egaña A. When Mechanical Stress Matters. Generation of Polyploid Giant Cancer Cells in Tumor-Like Microcapsules. Adv. Funct. Material doi:10.1002/adfm.202311139 (2024).  (C03, Z03)

Bettendorf E, Schmid R, Horch RE, Kengelbach-Weigand A, Kulike Y, Schrüfer S, Schubert DW, Lamberger Z, Stahlhut P, Lang G, Sörgel CA. Bioprinted keratinocyte and stem cell laden constructs for skin tissue engineering. IJB doi: 10.36922/ijb.3925 (2024). (C03, A07, C04)

Schmid R, Schmidt SK, Schrüfer S, Schubert DW, Heltmann-Meyer S, Schicht M, Paulsen F, Horch RE, Bosserhoff AK, Kengelbach-Weigand A, Arkudas A. A vascularized in vivo melanoma model suitable for metastasis research of different tumor stages using fundamentally different bioinks. Materials Today Bio (2024) doi: 10.1016/j.mtbio.2024.101071 (2024). (A07, C03, C04, Z03)

Staebler S, Rottensteiner-Brandl U, El Ahmad Z, Kappelmann-Fenzl M, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK, Schmidt SK. Transcription factor activating enhancer-binding protein 2ε (AP2ε) modulates phenotypic plasticity and progression of malignant melanoma. Cell Death Dis doi: 10.1038/s41419-024-06733-3 (2024). (C03, Z03)

Schipka R, Heltmann-Meyer S, Schneidereit D, Friedrich O, Röder J, Boccaccini AR, Schrüfer S, Schubert DW, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A, Schmid R: Characterization of two different alginate-based bioinks and the influence of melanoma growth within. NaturePortfolio, Scientific Reports doi.org/10.1038/s41598-024-63642-3 (2024). (C03, A01, A07, B08, C04, Z03)

2023

Schulik J, Salehi S, Boccaccini AR, Schrüfer S, Schubert DW, Arkudas A, Kengelbach-Weigand A, Horch RE, Schmid R, Comparison of the Behavior of 3D-Printed Endothelial Cells in Different Bioinks, Bioengineering 10(7) (2023). (C03, A07, C04, B03)

Sörgel CA, Cai A, Schmid R, Horch RE. Perspectives on the Current State of Bioprinted Skin Substitutes for Wound Healing. Biomedicines, doi: 10.3390/biomedicines11102678 (2023). (C03, C04)

Vaghela R, Arkudas A, Gage D, Korner C, von Horsten S, Salehi S, Horch RE, Hessenauer M, A Novel Window into Angiogenesis-Intravital Microscopy in the AV-Loop-Model, Cells 12(2) (2023). (B03, C03, C04)

2022

An R, Strissel PL, Al-Abboodi M, Robering JW, Supachai R, Eckstein M, Peddi A, Hauck T, Bäuerle T, Boccaccini AR, Youssef A, Sun J, Strick R, Horch RE, Boos AM, Kengelbach-Weigand A, An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research, Bioengineering 9(7) (2022). (C03, B01, A01)

Ertekin O, Monavari M, Kruger R, Fuentes-Chandia M, Parma B, Letort G, Tripal P, Boccaccini AR, Bosserhoff AK, Ceppi P, Kappelmann-Fenzl M, Leal-Egana A, 3D hydrogel-based microcapsules as an in vitro model to study tumorigenicity, cell migration and drug resistance, Acta Biomater 142 (2022) 208-220. (C03)

Sivakumar S, Schmid R, Wieland A, Strissel PL, Strick R, Fischer L, Thievessen I, Kataev E, Arkudas A, Horch RE, Schubert DW, Kengelbach‐Weigand A, Role of Fiber Thickness and Surface Treatment of Electrospun Polycaprolactone Matrices on the Growth of Different Breast Cancer‐Associated Cells, Advanced Materials Interfaces doi:10.1002/admi.202101808  (2022). (B01, B06, C03)

Sörgel CA, Schmid R, Stadelmann N, Weisbach V, Distel L, Horch RE, Kengelbach-Weigand A, IGF-I and Hyaluronic Acid Mitigate the Negative Effect of Irradiation on Human Skin Keratinocytes, Cancers 14(3) (2022). (C03, C04)

2021

Kappelmann-Fenzl M, Schmidt SK, Fischer S, Schmid R, Lammerhirt L, Fischer L, Schrufer S, Thievessen I, Schubert DW, Matthies A, Detsch R, Boccaccini AR, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK, Molecular Changes Induced in Melanoma by Cell Culturing in 3D Alginate Hydrogels, Cancers (Basel) 13(16) (2021). (C03, A01, A07, B06)

Schmid R, Schmidt SK, Detsch R, Horder H, Blunk T, Schrüfer S, Schubert DW, Fischer L, Thievessen I, Heltmann‐Meyer S, Steiner D, Schneidereit D, Friedrich O, Grüneboom A, Amouei H, Wajant H, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach‐Weigand A, A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo Metastatic Melanoma Models, Adv. Funct. Mater. doi:10.1002/adfm.202107993 (2021). (C03, A01, A07, B06, B08, C02, C04)

Winkler S, Mutschall H, Biggemann J, Fey T, Greil P, Korner C, Weisbach V, Meyer-Lindenberg A, Arkudas A, Horch RE, Steiner D, Human Umbilical Vein Endothelial Cell Support Bone Formation of Adipose-Derived Stem Cell-Loaded and 3D-Printed Osteogenic Matrices in the Arteriovenous Loop Model, Tissue Eng Part A 27(5-6) (2021) 413-423. (C04, C03)

Fuentes-Chandia M, Vierling A, Kappelmann-Fenzl M, Monavari M, Letort G, Hone L, Parma B, Antara SK, Ertekin O, Palmisano R, Dong M, Bopple K, Boccaccini AR, Ceppi P, Bosserhoff AK, Leal-Egana A, 3D Spheroids Versus 3D Tumor-Like Microcapsules: Confinement and Mechanical Stress May Lead to the Expression of Malignant Responses in Cancer Cells, Adv. Biol. doi:10.1002/adbi.202000349  (2021) 2000349. (C03, A01)

2020

Tolksdorf J, Horch RE, Gruner JS, Schmid R, Kengelbach-Weigand A, Schubert DW, Werner S, Schneidereit D, Friedrich O, Ludolph I, Size matters-in vitro behaviour of human fibroblasts on textured silicone surfaces with different pore sizes, J. Mater. Sci.: Mater. Med. 31(2) (2020) 23. (C04, B08, A07, C03)

Schmid R, Schmidt SK, Hazur J, Detsch R, Maurer E, Boccaccini AR, Hauptstein J, Tessmar J, Blunk T, Schrufer S, Schubert DW, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A, Comparison of Hydrogels for the Development of Well-Defined 3D Cancer Models of Breast Cancer and Melanoma, Cancers 12(8) (2020) 2320. (C03, A01, A02, A07, C02)

Mutschall H, Winkler S, Weisbach V, Arkudas A, Horch RE, Steiner D, Bone tissue engineering using adipose-derived stem cells and endothelial cells: Effects of the cell ratio, J. Cell. Mol. Med. 24(12) (2020) 7034-7043. (C04, C03)

Bohme I, Bosserhoff A, Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells, Pigm. Cell Melanoma Res. 33(1) (2020) 41-51. (C03)

2019

Steiner D, Lang G, Fischer L, Winkler S, Fey T, Greil P, Scheibel T, Horch RE, Arkudas A, Intrinsic Vascularization of Recombinant eADF4(C16) Spider Silk Matrices in the Arteriovenous Loop Model, Tissue Eng Part A 25(21-22) (2019) 1504-1513. (C04, A07, C01, C03)

Schmidt SK, Schmid R, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK, Tumor Cells Develop Defined Cellular Phenotypes After 3D-Bioprinting in Different Bioinks, Cells 8(10) (2019) 1295. (C03)

Kengelbach-Weigand A, Tasbihi K, Strissel PL, Schmid R, Marques JM, Beier JP, Beckmann MW, Strick R, Horch RE, Boos AM, Plasticity of patient-matched normal mammary epithelial cells is dependent on autologous adipose-derived stem cells, Sci. Rep. 9(1) (2019) 10722. (C03)

2018

Weigand A, Horch RE, Boos AM, Beier JP, Arkudas A, The Arteriovenous Loop: Engineering of Axially Vascularized Tissue, Eur. Surg. Res. 59(3-4) (2018) 286-299. (C03, C04)

Steiner D, Lingens L, Fischer L, Kohn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier JP, Horch RE, Arkudas A, Encapsulation of Mesenchymal Stem Cells Improves Vascularization of Alginate-Based Scaffolds, Tissue Eng Part A 24(17-18) (2018) 1320-1331. (C03, C04, A01, B06, B03) Front Cover for Tissue Engineering Part A

Rottensteiner-Brandl U, Detsch R, Sarker B, Lingens L, Kohn K, Kneser U, Bosserhoff AK, Horch RE, Boccaccini AR, Arkudas A, Encapsulation of Rat Bone Marrow Derived Mesenchymal Stem Cells in Alginate Dialdehyde/Gelatin Microbeads with and without Nanoscaled Bioactive Glass for In Vivo Bone Tissue Engineering, Materials (Basel) 11(10) (2018) 1880. (C04, A01, C03)

An R, Schmid R, Klausing A, Robering JW, Weber M, Bauerle T, Detsch R, Boccaccini AR, Horch RE, Boos AM, Weigand A, Proangiogenic effects of tumor cells on endothelial progenitor cells vary with tumor type in an in vitro and in vivo rat model, FASEB J. 32(10) (2018) 5587-5601. (C03)

2022

Annika Kengelbach-Weigand, Rafael Schmid, Sonja K. Schmidt, Rainer Detsch, Hannes Horder, Torsten Blunk, Stephan Schrüfer, Dirk W. Schubert, Lena Fischer, Ingo Thievessen, Dominik Schneidereit, Oliver Friedrich, A. Grüneboom, Pamela L. Strissel, Reiner Strick, Raymund E. Horch, Anja K. Bosserhoff, Andreas Arkudas
Establishment of a 3D-biofabricated Tumor Model Suitable for Analyzing Tumor Progression, Cell-cell-and Cell-matrix-interactions
IFATS 2022 International Federation for Adipose Therapeutics and Science

Sonja K. Schmidt, Melanie Kappelmann-Fenzl, Stefan Fischer, Rafael Schmid, Andreas Arkudas, Annika Kengelbach-Weigand, Anja K. Bosserhoff
Molecular analysis of tumor dormancy in a 3D printed melanoma model
19th International Congress of the Society for Melanoma Research https://smrcongress.org/                              C03

2019

Schmid R, Schmidt S, Hazur J, Detsch R, Boccaccini AR, Bosserhoff A, Horch RE, Arkudas A, Kengelbach-Weigand A (2019)
Analyse von Tumor Dormancy und Progression in biofabrizierten und in vivo vaskularisierten 3D Modellen
50. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC) September 26-28, 2019 (Hamburg, Germany)

Kengelbach-Weigand A (2019)
In vitro und in vivo Modelle zur Erforschung der Mammakarzinompathogenese
50. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC) September 26-28, 2019 (Hamburg, Germany)

Kengelbach-Weigand A, Schmid R, Tasbihi K, Strissel PL, Strick R, Al-Abboodi M, An R, Robering JW, Eckstein M, Bäuerle T, Detsch R, Boccaccini AR, Dalton PD, Youssef A, Wolf K, Kremer AE, Boos AM, Bosserhoff A, Arkudas A, Horch RE (2019)
The arteriovenous loop as 3D model for studying the interaction of ADSC and breast cancer cells
TERMIS EU Workshop 2019, 26th-27th Aug 2019, Nantes, France

Kengelbach-Weigand A (2019)
Das arteriovenöse Gefäßschleifenmodell als Tool für die Untersuchung der Interaktion von ADSC und Mammakarzinomzellen
3. DAM Wissenschaftsakademie, 12 – 13 April 2019 (Erlangen, Germany)

Schmid R (2019)
Analyse von Tumor dormancy und Progression in biofabrizierten und in vivo vaskularisierten 3D-Modellen
3. DAM Wissenschaftsakademie, 12 – 13 April 2019 (Erlangen, Germany)

2018

Weigand A, Boos AM, An R, Strissel PL, Schmid R, Robering JW, Al-Abboodi M, Detsch R, Dalton PD, Youssef A , Boccaccini AR, Beckmann MW, Bäuerle T, Strick R, Horch RE (2018)
Vom Tissue Engineering zum Tumor Engineering
49. Jahrestagung der Deutsche Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen DGPRÄC & 23. Jahrestagung der Vereinigung der Deutschen Ästhetisch Plastischen Chirurgen (VDÄPC), 13 – 15 September 2018 (Bochum, Germany)

Weigand A, Beier JP, Schmid R, Robering JW, Cai A, Arkudas A, Horch RE, Boos A (2018)
Vascularized Tissue Engineering Using the Arteriovenous Loop – The Path from the Small Animal Model to the Preclinical Large Animal Model
2018 TERMIS World Congress, 4-7 September 2018 (Kyoto, Japan)

Peddi A, Steiner D, Weigand A, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier JP, Horch RE, Arkudas A. (2018)
Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds
The 10th EPSRC Meeting, 23 – 25 August 2018 (Hamburg, Germany)

2024

Tannaz Karimi, Evelin Sandor, Carolin Eckert, Anja K. Bosserhoff, Andreas Arkudas, Annika Kengelbach-Weigand
Analysis of tumor dormancy and progression in biofabricated vascularized 3D models

Schmid R, Schmidt SK, Schrüfer S, Schubert DW, Heltmann-Meyer S, Schicht M, Paulsen F, Horch RE, Bosserhoff AK, Kengelbach-Weigand A, Arkudas A
An In Vivo Melanoma Model Suitable For Metastasis Research Of Different Tumor Stages Using Fundamentally Different Bioinks
TERMIS June 2024

2022

Evelin Sandor, Tannaz Karimi, Carolin Eckert, Andreas Arkudas, Anja Bosserhoff, Rafael Schmid, Sonja Schmidt, Annika Kengelbach-Weigand
SFB/TRR 225 Project C03: Analysis of tumor dormancy and progression in biofabricated vascularized 3D models
Symposium “Biofabrication meets Infection” Würzburg on 25-28- September 2022               C03

Sonja K. Schmidt, Melanie Kappelmann-Fenzl, Stefan Fischer, Rafael Schmid, Andreas Arkudas, Annika Kengelbach-Weigand, Anja K. Bosserhoff
Molekulare Analyse der Tumor Dormancy des malignen Melanoms im 3D-gedruckten Modell ADO
Hautkrebs Kongress 2022, Hannover https://www.ado-kongress.de/           C03

Sonja K. Schmidt, Melanie Kappelmann-Fenzl, Stefan Fischer, Rafael Schmid, Andreas Arkudas, Annika Kengelbach-Weigand, Anja K. Bosserhoff
Molecular analysis of tumor dormancy in a 3D printed melanoma model
19th International Congress of the Society for Melanoma Research https://smrcongress.org/              C03

Rafael Schmid, Sonja K. Schmidt, Rainer Detsch, Hannes Horder, Torsten Blunk, Stefan Schrüfer, Dirk W. Schubert, Lena Fischer, Ingo Thievessen, Stefanie Heltmann-Meyer, Dominik Steiner, Dominik Schneidereit, Oliver Friedrich, Anika Grüneboom, Hanna Amouei, Harald Wajant, Raymund E. Horch, Anja K. Bosserhoff, Andreas Arkudas, Annika Kengelbach-Weigand
A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo
Metastatic Melanoma Models TERMIS EU 2022               C03 and A01, A07, B06, B08, C02, C04

2021

Kengelbach-Weigand A, Schmid R, Schmidt SK, Hazur J, Detsch R, Maurer E, Boccaccini AR, Hauptstein J, Teßmar J, Blunk T, Schrüfer S, Schubert DW, Horch RE, Bosserhoff AK, Arkudas A (2021)
Entwicklung eines biofabrizierten 3D-Tumormodells
51. Jahrestagung der DGPRÄC, 25. Jahrestagung der VDÄPC, Oktober 14-16 (virtuell)

Sivakumar S, Schmid R, Wieland A, Strissel PL, Strick R, Fischer L, Thievessen I, Kataev E, Arkudas A, Horch RE, Schubert DW, Kengelbach-Weigand A
“Role of Fiber Thickness and Surface Treatment of Electrospun Polycaprolactone Matrices on the Growth of Different Breast Cancer-Associated Cells”
31st Annual SBAOI meeting and 14th STERMI annual meeting and International conference on Biomaterials-based therapeutics, engineering and medicine (BIOTEM-2021), December 17-20, 2021.

Schmidt SK, Kappelmann-Fenzl M, Fischer S, Schmid R, Lämmerhirt L, Fischer L, Schrüfer S, Thievessen I, Schubert DW, Matthies A, Detsch R, Boccaccini AR, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK (2021)
Analyse molekularer Veränderungen im Melanom, induziert durch Zellkultivierung in 3D Alginat-Hydrogelen
31. Deutscher Hautkrebskongress der Arbeitsgemeinschaft Dermatologische Onkologie (ADO), 08.-11. September 2021

Schmid R, Schmidt SK, Detsch R, Horder H, Blunk T, Schrüfer S, Schubert DW, Fischer L, Thievessen I, Heltmann-Meyer S, Steiner D, Schneidereit D, Friedrich O, Grüneboom A, Amouei H, Wajant H, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A (2021)
A new printable alginate / hyaluronic acid / gelatin hydrogel suitable for biofabrication of in vitro and in vivo metastatic melanoma models
31st Annual Conference of the European Society for Biomaterials (ESB 2021), 5 to 9 September 2021 (C03, A01, A07, B06, B08, C02, C04)

Schmidt SK, Kappelmann-Fenzl M, Fischer S, Schmid R, Lämmerhirt L, Fischer L, Schrüfer S, Thievessen I, Schubert DW, Matthies A, Detsch R, Boccaccini AR, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK (2021)
Molecular changes induced in melanoma by cell culturing in 3D alginate hydrogels
31st Annual Conference of the European Society for Biomaterials (ESB 2021), 5.-9. September 2021

2020

Schmidt SK, Schmid R, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK (2020)
3D-Druck von Melanomzellen mit kommerziell erwerblichen Hydrogelen
Digitaler 30. Deutscher Hautkrebskongress der Arbeitsgemeinschaft Dermatologische Onkologie (ADO), 10.-11. September 2020

2019

Schmid R, Schmidt SK, Hazur J, Detsch R, Boccaccini AR, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A (2019)
Comparison of hydrogels for the development of well defined 3D cancer models of breast cancer and melanoma
4th EACR Conference on Goodbye Flat Biology, Berlin, Germany, 10.-13. November 2019

Schmidt SK, Schmid R, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK (2019)
3D-Bioprinting of melanoma cells with commercially available matrices
4th EACR Conference on Goodbye Flat Biology, Berlin, Germany, 10.-13. November 2019

2018

Weigand A, Boos AM, An R, Strissel PL, Schmid R, Robering JW, Al-Abboodi M, Detsch R, Dalton PD, Youssef A , Boccaccini AR, Beckmann MW, Bäuerle T, Strick R, Horch RE (2018)
From Tissue Engineering to Tumor Engineering –  Application of the arteriovenous loop model for the generation of a fully vascularized tumor in an animal model
2018 TERMIS World Congress, 4-7 September 2018 (Kyoto, Japan)

Alexander Deuschel

Previous academic education: Master of Science in Biochemistry at the University of Würzburg
Academic Advisor within SFB TRR225: Prof. Dr. Anja Bosserhoff
Location: FAU Erlangen-Nürnberg, Department for Biochemistry and Molecular Medicine
Topic of thesis: Analysis of tumor dormancy and progression in biofabricated and vascularized in vivo 3D models
Main techniques and methodologies to be used: Cell culture, qPCR, fluorescence microscopy, FACS, Western Blot

Contact: alex.deuschel@fau.de

Sonja Schmidt

Previous academic education: Master of Science
Academic Advisor within SFB TRR225: Prof. Dr. Anja Boßerhoff
Location: FAU Erlangen-Nürnberg, Department for Biochemistry and Molecular Medicine
Topic of thesis: Analysis of tumor dormancy and progression in biofabricated and in vivo vascularized 3D models
Main techniques and methodologies to be used: Analysis of cell behavior & signaling pathways (cell culture, fluorescence microscopy, qPCR, Western Blot, …)

Contact: sonja.s.schmidt@fau.de

Rafael Schmid

Previous academic education: Master of Tissue Engineering and Regenerative Medicine
Academic Advisor within SFB TRR225: Prof. Dr. Andreas Arkudas, Dr. Annika Kengelbach-Weigand
Location: University Hospital of Erlangen, Department of Plastic and Hand Surgery
Topic of thesis: Analysis of tumor dormancy and progression in biofabricated and vascularized in vivo 3D models
Main techniques and methodologies to be used: cell culture, cell culture assays, (live cell) microscopy, in vivo AV loop, in vivo 3D imaging (immuno)histology, gene expression

Contact: rafael.schmid@uk-erlangen.de

Ajay Peddi

Previous academic education: Master in Biomedical Engineering, Martin Luther University Halle, Germany Effects of Fresh Blood Versus Old Blood (stored) on Hepatocyte Viability, Proliferation, Gene Expression; Comparison of the Effects in Hepatocyte 2D and 3D Cell Culture Models
Bachelor of Pharmacy, Rajeev Gandhi University of Health Sciences, India
Academic Advisor within SFB TRR225: Prof. Dr. Andreas Arkudas, Dr. Annika Weigand
Location: University Hospital of Erlangen, Department of Plastic and Hand Surgery
Topic of thesis: Analysis of tumor dormancy and progression in biofabricated and vascularized in vivo 3D models
Main techniques and methodologies to be used: cell culture, cell culture assays, (live cell) microscopy, in vivo AV loop, in vivo 3D imaging (immuno)histology, gene expression

Prof. Dr. Anja Bosserhoff

  • Member of the German Council of Science and Humanities, since Feb 2021 Chair of the Scientific Commission of the German Council of Science and Humanities
  • Member of the Scientific Advisory Board of the Wilhelm Sander Foundation
  • Senator of the FAU (Chair of the Senate)
  • Member of the DFG’s Standing Senate Commission on Basic Questions in Clinical Research
  • Member of the DFG Standing Senate Commission on Animal Experimental Research
  • Chairwoman of the Sofie Wallner Foundation
  • Founder and Board Member of the Society of Melanoma Research (SMR)
  • Board member of the European Society of Pigment Cell Research (ESPCR)

Prof. Dr. Andreas Arkudas

PD Dr. Annika Kengelbach-Weigand

  • Advisory Network of the Schering Foundation
  • Member of the Expert Pool of the National Committee TierSchG at the Federal Institute for Risk Assessment (BfR)
  • Member of the §15 Animal Welfare Commission, Government of Lower Franconia
  • Active member of TVT e. V. (Veterinary Association for Animal Protection), Working Group 4 Animals in Experiments
  • Member of Tissue Engineering and Regenerative Medicine International Society (TERMIS)
  • Member of the GV-SOLAS (Gesellschaft für Versuchstierkunde / Society of Laboratory Animals)
  • Member of the Deutsche Gesellschaft für Senologie e.V. (DGS)
  • Member of the Deutschsprachige Arbeitsgemeinschaft für Mikrochirurgie der peripheren Nerven und Gefäße (DAM)