B09 | Biofabricated gradients for functional tissue models

The aim of this project is to develop a platform technology to biofabricate defined and reproducible gradients in space and time, to analyze them and to model them in silico in order to be able to investigate their effects on cell-biomaterial interactions. For this purpose, we will first develop print heads that enable us to print controlled transitions of materials from the A / B projects, active substances and cells. Through the comprehensive characterization of the printed gradients using mechanical testing methods in combination with image processing, we will constantly analyze and improve the result with regard to the requirements of the C projects. In addition, we will use continuum mechanics modeling and simulation to systematically optimize process parameters, the print pattern and the 3D arrangement within the construct.

Dr.-Ing. Silvia Budday
Dr. Tomasz Jüngst

 

Jessica Faber

Previous academic education: M.Sc. in Mechanical Engineering and M.Sc. in Industrial Engineering and Management
Academic Advisor within SFB TRR225: Dr.-Ing. Silvia Budday
Location: FAU Erlangen, Institute of Applied Mechanics
Topic of thesis: Complex mechanical analysis and modeling of spatio-temporal gradients in biofabricated constructs
Main techniques and methodologies to be used: Multi-modal large-strain mechanical testing (compression, tension, shear, indentation), continuum mechanics modeling, Finite Element (FE) simulations

Contact: jessica.faber@fau.de

Florian Hofmann

Previous academic education: Diploma-Thesis
Academic Advisor within SFB TRR225: Dr. Tomasz Jüngst
Location: University of Würzburg, Department for functional materials in medicine and dentistry
Topic of thesis: Microfluidic chips for creating gradients of bioinks through extrusion-based bioprinting
Main techniques and methodologies to be used: SLA/DLP, Extrusion-based 3D-Bioprinting, Microfluidics

Contact: florian.hofmann@fmz.uni-wuerzburg.de