B09 | Biofabricated gradients for functional tissue models
The aim of this project is to develop a platform technology to biofabricate defined and reproducible gradients in space and time, to analyze them and to model them in silico in order to be able to investigate their effects on cell-biomaterial interactions. For this purpose, we will first develop print heads that enable us to print controlled transitions of materials from the A / B projects, active substances and cells. Through the comprehensive characterization of the printed gradients using mechanical testing methods in combination with image processing, we will constantly analyze and improve the result with regard to the requirements of the C projects. In addition, we will use continuum mechanics modeling and simulation to systematically optimize process parameters, the print pattern and the 3D arrangement within the construct.
Dr.-Ing. Silvia Budday
Prof. Dr. Tomasz Jüngst