B05 | Glycoengineering as a tool to control the behavior of mesenchymal stem cells in biofabrication processes
The interaction of cells with bioinks, as well as direct cell-cell interaction, is essential for biofabrication of tissue constructs. This project aims to reduce shear stress during bioprinting, to increase cell proliferation in the hydrogel, to influence cell-cell aggregation and spheroid formation, and to optimize cell-ink interaction by coupling a specific galectin-1 ligand via cell surface modification by membrane engineering. The long-term goal is to apply membrane engineering for cell and bioink modification to optimize the post-fabrication behavior of cells in biofabricated constructs.