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A04 | Expansion of the biofabrication window using 2.5D scaffolds made from (AB)n-segmented copolymers

The aim of the project is the expansion of the biofabrication window of bioinks. By using 2.5D scaffolds – a structurally stable substrate – for the bioprinting process a better precision and reproducibility of the bioink depostion can be achieved. For this purpose, new (AB)n-segmented copolymers with hydrophilic soft segments and supramolecular hard segments are developed, which can be processed by Melt Electrospinning Writing. By selective swelling with biological media hydrogel scaffolds are formed covering a wide range of Young’s Moduli and enabling different cellular interactions. Until today, this cannot be realized with conventional biofabrication processes.

Prof. Dr. Hans-Werner Schmidt
Prof. Dr. Paul Dalton

Ezgi Bakirci

Previous academic education: Yildiz Technical University-Bioengineering, Sabanci University- Material Sciences and Engineering 
Academic Advisor within SFB TRR225: Prof. Dr. Paul Dalton
Subproject: Ultra-soft matrix composite for 3D Neuroglia in vitro Research
Location: University of Würzburg, Department for Functional Materials in Medicine and Dentistry
Topic of thesis: Developing in vitro Culture System for Nerve Tissue Engineering Application using Melt Electrospinning Writing
Main techniques and methodologies to be used: Melt Electrospinning Writing, Hydrogel, Cell Culture

Contact: ezgi.bakirci@fmz.uni-wuerzburg.de

Congratulations to Ezgi Bakirci and Paul Dalton Project A04 & B01. Ezgi Bakirci won the IOP Biofabrication Best Presentation Award 2018 at the @utrechtsummer course 3D Printing & Biofabrication.

Congratulations to Ezgi Bakirci and Paul Dalton Project A04 & B01. Ezgi Bakirci won the ISBF Young Scientist Award at the Biofabrication 2021 conference.

Andreas Frank

Previous academic education: Master-Thesis: “Hydrogel gradients based on polyacrylamide”
Academic Advisor within SFB TRR225:  Prof. Hans-Werner Schmidt
Location: University of Bayreuth, Department for Macromolecular Chemistry I
Topic of thesis: Tailored polymers for the biofabrication
Main techniques and methodologies to be used: NMR-spectroscopy, Fourier Transform Infrared Spectroscopy (FT-IR), Size Exclusion Chromato-graphy (SEC), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Dynamic Mechanical Thermal Analysis (DMTA), Rheology, Melt Electrospinning Writing  (MEW), Environmental Scanning Electron Microscopy (ESEMTM)

Contact: andreas.frank@uni-bayreuth.de

Haag H, Sonnleitner D, Lang G, Dalton PD, Melt electrowriting to produce microfiber fragments, Polymers for Advanced Technologies doi:10.1002/pat.5641  (2022). (A04, A07)

Karakaya E, Bider F, Frank A, Teßmar J, Schöbel L, Forster L, Schrüfer S, Schmidt H-W, Schubert DW, Blaeser A, Boccaccini AR, Detsch R, Targeted Printing of Cells: Evaluation of ADA-PEG Bioinks for Drop on Demand Approaches, Gels 8(4) (2022). (B06, A02, A04, A07)

Mechau J, Frank A, Bakirci E, Gumbel S, Jungst T, Giesa R, Groll J, Dalton PD, Schmidt HW, Hydrophilic (AB)n Segmented Copolymers for Melt Extrusion‐Based Additive Manufacturing, Macromol. Chem. Phys. 222(1) (2020). (A04)

Grosshaus C, Bakirci E, Berthel M, Hrynevich A, Kade JC, Hochleitner G, Groll J, Dalton PD, Melt Electrospinning of Nanofibers from Medical-Grade Poly(epsilon-Caprolactone) with a Modified Nozzle, Small 16(44) (2020) 2003471. (A04)

Dalton PD, Woodfield TBF, Mironov V, Groll J, Advances in Hybrid Fabrication toward Hierarchical Tissue Constructs, Adv Sci (Weinh) 7(11) (2020) 1902953. (A04, B02)

McMaster R, Hoefner C, Hrynevich A, Blum C, Wiesner M, Wittmann K, Dargaville TR, Bauer-Kreisel P, Groll J, Dalton PD, Blunk T, Tailored Melt Electrowritten Scaffolds for the Generation of Sheet-Like Tissue Constructs from Multicellular Spheroids, Adv Healthc Mater 8(7) (2019) 1801326. (C02, A04)

Hochleitner G, Fursattel E, Giesa R, Groll J, Schmidt HW, Dalton PD, Melt Electrowriting of Thermoplastic Elastomers, Macromol. Rapid Commun. 39(10) (2018) 1800055. (A04)

Frank A, Mechau J, Bakirci E, Gumbel S, Giesa R, Groll J, Dalton PD, Schmidt HW (2020) Hydrogels based on (AB)n-segmented copolymers with polyethylene glycol segments for biofabrication, 5th Bioinspired Materials 2020 Conference, 16 – 19 March 2020 – Web conference

Mechau J, Frank A, Böhm C, Giesa R, Dalton PD, Schmidt HW (2018) Melt Electrowriting of water-swelling (AB)n segmented block copolymers, Annual Conference of the International Society for Biofabrication (ISBF), 28 – 31 October, 2018 (Würzburg, Germany).

Verfahren und Messanordnung zum Ermitteln einer Fließeigenschaft eines Fluids “BERIT” (Best Elongation Rheology Investigative Testing), inventors: Dirk W. Schubert (A07), Paul Dalton (A04 and B01), Stefan Schrüfer (A07), DE application number: DE 10 2020 216 545.9., applicant FAU

Jannik Mechau

Previous academic education: Master Thesis: “Synthesis of Model compounds for donor-acceptor systems in polymer solar cells” (Georg-August Universität Göttingen)
Academic Advisor within SFB TRR225: Prof. Hans-Werner Schmidt
Location: University of Bayreuth, Department for Macromolecular Chemistry I
Topic of thesis: Synthesis and properties of polyethylene glycol containing (AB)n segmented copolymers
Main techniques and methodologies to be used: Polymer synthesis, NMR-spectroscopy, Fourier Transform Infrared Spectroscopy (FT-IR), Size Exclusion Chromatpography (SEC), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Dynamic Mechanical Thermal Analysis (DMTA), Rheology, Melt Electro-spinning Writing (MEW) in cooperation with FMZ Würzburg (Group of Paul Dalton)

Contact: Jannik.Mechau@uni-bayreuth.de

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