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A01 | Alginate-based bioinks with tailored microstructural properties for controlled cell behavior

The aim of subproject A01 is the modification of adhesive, microstructural as well as microscopic and macroscopic mechanical properties of alginate-based biofabricated hierarchical tissue analogues for controlling desired cell behavior. This goal will be achieved by adjusting the porosity through sacrificial structures and by establishing localized durotactic gradients using two-phase (core/shell) printing. By simultaneously printing bioinks with different mechanical, adhesive and structural properties that are loaded with different cell types, a high degree of complexity can be achieved to control durotaxis, cell migration, cell differentiation and tissue structure formation.

Prof. Dr.-Ing. habil. Dr. h.c. Aldo R. Boccaccini
Prof. Dr. Ben Fabry

Jonas Röder

Previous academic education: B.Sc. in Nanotechnology: “The Effect of Sintering Temperature on Crystalization and Mineralization of Sol-Gel Derived 45S5 and 1393 Bioactive Glasses”, M.Sc. in Materials Science: “Materialcharacterization of Methacrylated Alginate Based Bioinks for Drop on Demand Approaches”
Academic Advisor within SFB TRR225: Prof. Dr.-Ing. habil. Aldo R. Boccaccini, Dr.-Ing. Rainer Detsch (technical advisor)
Location: Friedrich-Alexander University of Erlangen-Nuremberg, Institute of Biomaterials
Topic of thesis: Systematical investigation of adhesive functionalized and controlled degrading alginate based hydrogels
Main techniques and methodologies to be used: Bioplotting, chemical and physical modification, cell culture, degradation studies, spectroscopy, microscopy, rheology

Contact: jonas.jon.roeder@fau.de

David Böhringer

Previous academic education: M. Sc. Physics
Academic Advisor within SFB TRR225: Prof. Dr. Ben Fabry
Location: Friedrich-Alexander University of Erlangen-Nuremberg, Biophysics group, Center for Medical Physics and Technology
Topic of thesis: Mechanical properties of bioartificial tissues
Main techniques and methodologies to be used: microscopy, image processing, traction force microscopy, rheology, cell migration assays

Contact: david.boehringer@fau.de

2024

Bider F, Miola M, Clejanu C-E, Götzelmann J, Kuth S, Vernè E, Basu B, Boccaccini AR. 3D bioprinting of multifunctional alginate dialdehyde (ADA)–gelatin (GEL) (ADA-GEL) hydrogels incorporating ferulic acid. International Journal of Biological Macromolecule, doi: 10.1016/j.ijbiomac.2023.128449 (2024). (A01)

Horder H, Böhringer D, Endrizzi N, Hildebrand LS, Cianciosi A, Stecher S, DusiF, Schweinitzer S, Watzling M, Groll J,  Jüngst T, Teßmar L, Bauer-Kreisel P, Fabry B, Torsten B. Cancer cell migration depends on adjacent ASC and adipose spheroids in a 3D bioprinted breast cancer model. Biofabrication doi: 10.1088/1758-5090/ad57f7 (2024). (C02, A01, A02, B09)

Kah D, Lell J, Wach T, Spörrer M, Dessalles CA, Wiedenmann S, Gerum RC, Vergarajauregui SL, Esser TU, Böhringer D, Engel FB, Thievessen I, Fabry B. Contractility of cardiac and skeletal muscle tissue increases with environmental stiffness. bioRxiv, doi: 10.1101/2024.02.23.581737 (2024). (A01, B08, C01, C02)

Karakaya E, Gleichauf L, Schöbel L, Hassan A, Soufivand AA, Tessmar J, Budday S,  Boccaccini AR, Detsch R. Engineering peptide-modified alginate-based bioinks with cell-adhesive properties for biofabrication. RSC Adv. doi: 10.1039/D3RA08394B. (2024). (B06, A02, A01, B09)

Reineke B, Paulus I, Löffelsend S, Yu C-H, Hazur J, Röder J, Hauschild S, Boccaccini AR, Groll J, Förster S. On-chip fabrication and in-flow 3D-printing of microgel constructs: from chip to scaffold materials in one integral process. Biofabrication doi:10.1088/1758-5090/ad3318 (2024). (A06, A01, B06, Z03)

Schipka R, Heltmann-Meyer S, Schneidereit D, Friedrich O, Röder J, Boccaccini AR, Schrüfer S, Schubert DW, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A, Schmid R: Characterization of two different alginate-based bioinks and the influence of melanoma growth within. NaturePortfolio, Scientific Reports doi.org/10.1038/s41598-024-63642-3 (2024). (C03, A01, A07, B08, C04, Z03)

Vaziri AS, Vasheghani-Farahani E, Hosseinzadeh S, Bagheri F, Büchner M, Schubert DW, Boccaccini AR. Genipin-Cross-Linked Silk Fibroin/Alginate Dialdehyde Hydrogel with Tunable Gelation Kinetics, Degradability, and Mechanical Properties: A Potential Candidate for Tissue Regeneration. Biomacromolecules, doi: 10.1021/acs.biomac.3c01203 (2024). (A01, A07)

2023

Böhringer D, Bauer A, Moravec I, Bischof L, Kah D, Mark C, Grundy TJ, Görlach E, Neill GMO, Budday S, Strissel P, Strick R, Malandrino A, Mak M, Rausch M, Fabry B. Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility. Matrix Biology doi: 10.1016/j.matbio.2023.11.004 (2023). (A01, B09, C02, C05)

Czerwinski T, Bischof L, Böhringer D, Kara S, Wittmann E, Winterl A, Gerum R, Nusser G, Wiesinger M, Budday S, Lux A, Voskens C, Fabry B, Mark C, doi:10.1101/2023.04.20.537658  (2023). (A01, B09, C02)

Esser TU, Anspach A, Muenzebrock KA, Kah , Schrüfer S, Schenk J, Heinze KG, Schubert DW, Fabry B, Engel FB. Direct 3D-Bioprinting of hiPSC-derived Cardiomyocytes to Generate Functional Cardiac Tissues. Advanced Materials, doi: 10.1002/adma.202305911 (2023). (C01, Z02, A07, A01, C02)

Hazur J, Röder J, Czwalinna J, Schubert DW, Boccaccini AR, Pre‐Crosslinking with Hydrogel Microparticles Enhances the Printability of Alginate‐Based Inks, Macromolecular Materials and Engineering doi:10.1002/mame.202200675  (2023). (A01, A07)

Karakaya E, Schobel L, Zhong Y, Hazur J, Heid S, Forster L, Tessmar J, Boccaccini AR, Detsch R, How to Determine a Suitable Alginate for Biofabrication Approaches using an Extensive Alginate Library?, Biomacromolecules doi:10.1021/acs.biomac.2c01282  (2023). (B06, A02, A01)

Martinez-Sanchez LDC, Ngo PA, Pradhan R, Becker LS, Boehringer D, Soteriou D, Kubankova M, Schweitzer C, Koch T, Thonn V, Erkert L, Stolzer I, Gunther C, Becker C, Weigmann B, Klewer M, Daniel C, Amann K, Tenzer S, Atreya R, Bergo M, Brakebusch C, Watson AJM, Guck J, Fabry B, Atreya I, Neurath MF, Lopez-Posadas R, Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation, Gut 72(2) (2023) 275-294. (A01)

Peters G, Jakubass B, Weidenfeller K, Kniesburges S, Bohringer D, Wendler O, Mueller SK, Gostian AO, Berry DA, Dollinger M, Semmler M, Synthetic mucus for an ex vivo phonation setup: Creation, application, and effect on excised porcine larynges, J Acoust Soc Am 152(6) (2022) 3245. (A01)

Schöbel L, Karakaya E, Detsch R, Boccaccini AR, Preparation of Compact Alginate Films for 2D in vitro Studies: Challenges and Strategies for Improvement, Materials Letters doi:10.1016/j.matlet.2023.134103  (2023). (A01, B06)

Tesler AB, Kolle S, Prado LH, Thievessen I, Böhringer D, Backholm M, Karunakaran B, Nurmi HA, Latikka M, Fischer L, Stafslien S, Cenev ZM, Timonen JVI, Bruns M, Mazare A, Lohbauer U, Virtanen S, Fabry B, Schmuki P, Ras RHA, Aizenberg J, Goldmann WH. Long-term stability of aerophilic metallic surfaces underwater. Nature Materials doi: 10.1038/s41563-023-01670-6 (2023).        (A01, C02)

2022

Kitana W, Apsite I, Hazur J, Boccaccini AR, Ionov L, 4D Biofabrication of T‐Shaped Vascular Bifurcation, Advanced Materials Technologies doi:10.1002/admt.202200429  (2022). (A01, A08)

Janzen D, Bakirci E, Faber J, Mier MA, Hauptstein J, Pal A, Forster L, Hazur J, Boccaccini AR, Detsch R, Tessmar J, Budday S, Blunk T, Dalton PD, Villmann C, Reinforced Hyaluronic acid-based Matrices promote 3D Neuronal Network Formation, Adv Healthc Mater doi:10.1002/adhm.202201826  (2022) e2201826. (A01, A02, B06, B09, B01/C05)

Fischer L, Nosratlo M, Hast K, Karakaya E, Strohlein N, Esser T, Gerum RC, Richter S, Engel FB, Detsch R, Fabry B, Thievessen I, Calcium supplementation of bioinks reduces shear stress-induced cell damage during bioprinting, Biofabrication doi:10.1088/1758-5090/ac84af (2022). (A01, B06, C01, C02)

An R, Strissel PL, Al-Abboodi M, Robering JW, Supachai R, Eckstein M, Peddi A, Hauck T, Bäuerle T, Boccaccini AR, Youssef A, Sun J, Strick R, Horch RE, Boos AM, Kengelbach-Weigand A, An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research, Bioengineering 9(7) (2022). (C03, B01, A01)

Heid S, Becker K, Byun J, Biermann I, Neščáková Z, Zhu H, Groll J, Boccaccini AR, Bioprinting with bioactive alginate dialdehyde-gelatin (ADA-GEL) composite bioinks: Time-dependent in-situ crosslinking via addition of calcium-silicate particles tunes in vitro stability of 3D bioprinted constructs, Bioprinting doi:10.1016/j.bprint.2022.e00200  (2022). (B03, A01, A06)

Gerum R, Mirzahossein E, Eroles M, Elsterer J, Mainka A, Bauer A, Sonntag S, Winterl A, Bartl J, Fischer L, Abuhattum S, Goswami R, Girardo S, Guck J, Schrufer S, Strohlein N, Nosratlo M, Herrmann H, Schultheis D, Rico F, Muller SJ, Gekle S, Fabry B, Viscoelastic properties of suspended cells measured with shear flow deformation cytometry, Elife 11 (2022). (A01, A07, B07)

Peters G, Jakubass B, Weidenfeller K, Kniesburges S, Bohringer D, Wendler O, Mueller SK, Gostian AO, Berry DA, Dollinger M, Semmler M, Synthetic mucus for an ex vivo phonation setup: Creation, application, and effect on excised porcine larynges, J Acoust Soc Am 152(6) (2022) 3245. (A01)

Schmid R, Schmidt SK, Detsch R, Horder H, Blunk T, Schrufer S, Schubert DW, Fischer L, Thievessen I, Heltmann-Meyer S, Steiner D, Schneidereit D, Friedrich O, Gruneboom A, Amouei H, Wajant H, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A, A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo Metastatic Melanoma Models, Advanced Functional Materials 32(2) (2022). (C03, A01, A07, B06, B08, C02, C04)

Sporrer M, Kah D, Gerum RC, Reischl B, Huraskin D, Dessalles CA, Schneider W, Goldmann WH, Herrmann H, Thievessen I, Clemen CS, Friedrich O, Hashemolhosseini S, Schroder R, Fabry B, The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissues, Neuropathol Appl Neurobiol 48(3) (2022) e12784. (A01, B08, C02)

2021

Hazur J, Endrizzi N, Schubert DW, Boccaccini AR, Fabry B, Stress relaxation amplitude of hydrogels determines migration, proliferation, and morphology of cells in 3-D, bioRxiv (2021)2021.07.08.451608 (A01, A07, C02)

Bauer A, Prechova M, Fischer L, Thievessen I, Gregor M, Fabry B, pyTFM: A tool for traction force and monolayer stress microscopy, PLoS Comput Biol 17(6) (2021) e1008364. (A01, B06)

Bednarzig V, Karakaya E, Egana AL, Teßmar J, Boccaccini AR, Detsch R, Advanced ADA-GEL bioink for bioprinted artificial cancer models, Bioprinting doi:10.1016/j.bprint.2021.e00145  (2021) 00145. (B06, A01, A02)

Fuentes-Chandia M, Vierling A, Kappelmann-Fenzl M, Monavari M, Letort G, Hone L, Parma B, Antara SK, Ertekin O, Palmisano R, Dong M, Bopple K, Boccaccini AR, Ceppi P, Bosserhoff AK, Leal-Egana A, 3D Spheroids Versus 3D Tumor-Like Microcapsules: Confinement and Mechanical Stress May Lead to the Expression of Malignant Responses in Cancer Cells, Adv. Biol. doi:10.1002/adbi.202000349  (2021) 2000349. (C03, A01)

Genc H, Hazur J, Karakaya E, Dietel B, Bider F, Groll J, Alexiou C, Boccaccini AR, Detsch R, Cicha I, Differential Responses to Bioink-Induced Oxidative Stress in Endothelial Cells and Fibroblasts, Int. J. Mol. Sci. 22(5) (2021) 2358. (B02, A01, B06)

Kah D, Winterl A, Přechová M, Schöler U, Schneider W, Friedrich O, Gregor M, Fabry B, A low-cost uniaxial cell stretcher for six parallel wells, HardwareX 9 (2021). (A01, B08, C02)

2020

Distler T, Solisito AA, Schneidereit D, Friedrich O, Detsch R, Boccaccini AR, 3D printed oxidized alginate-gelatin bioink provides guidance for C2C12 muscle precursor cell orientation and differentiation via shear stress during bioprinting, Biofabrication 12(4) (2020) 045005. (A01, B06, B08)

Dranseikiene D, Schrufer S, Schubert DW, Reakasame S, Boccaccini AR, Cell-laden alginate dialdehyde-gelatin hydrogels formed in 3D printed sacrificial gel, J. Mater. Sci.: Mater. Med. 31(3) (2020) 31. (A01, A07)

Hazur J, Detsch R, Karakaya E, Kaschta J, Tessmar J, Schneidereit D, Friedrich O, Schubert DW, Boccaccini AR, Improving alginate printability for biofabrication: establishment of a universal and homogeneous pre-crosslinking technique, Biofabrication 12(4) (2020) 045004. (A01, A02, A07, B06, B08)

Karakaya E, Fischer L, Hazur J, Boccaccini AR, Thievessen I, Detsch R, Strategies to evaluate alginate based bioinks applying extrusion printingfor biofabrication, Additive Manufacturing Meets Medicine, 2020. (B06, A01)

Mirzaei Z, Kuth S, Schubert DW, Detsch R, Roether JA, Blunk T, Kordestani SS, Boccaccini AR, Preparation and Characterization of Electrospun Blend Fibrous Polyethylene Oxide:Polycaprolactone Scaffolds to Promote Cartilage Regeneration, Adv. Eng. Mater. 22(9) (2020). (A01, A02, A07, B06)

Muller SJ, Mirzahossein E, Iftekhar EN, Bacher C, Schrufer S, Schubert DW, Fabry B, Gekle S, Flow and hydrodynamic shear stress inside a printing needle during biofabrication, PLoS One 15(7) (2020) 0236371. (B07, A01, A07)

Rausch M, Bohringer D, Steinmann M, Schubert DW, Schrufer S, Mark C, Fabry B, Measurement of Skeletal Muscle Fiber Contractility with High-Speed Traction Microscopy, Biophys. J. 118(3) (2020) 657-666. (A01, A07)

Reimann R, Kah D, Mark C, Dettmer J, Reimann TM, Gerum RC, Geitmann A, Fabry B, Dietrich P, Kost B, Durotropic Growth of Pollen Tubes, Plant Physiol. 183(2) (2020) 558-569. (A01, C02)

Schmid R, Schmidt SK, Hazur J, Detsch R, Maurer E, Boccaccini AR, Hauptstein J, Tessmar J, Blunk T, Schrufer S, Schubert DW, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A, Comparison of Hydrogels for the Development of Well-Defined 3D Cancer Models of Breast Cancer and Melanoma, Cancers 12(8) (2020) 2320. (C03, A01, A02, A07, C02)

2019

Distler T, Ruther F, Boccaccini AR, Detsch R, Development of 3D Biofabricated Cell Laden Hydrogel Vessels and a Low-Cost Desktop Printed Perfusion Chamber for In Vitro Vessel Maturation, Macromol. Biosci. 19(9) (2019) 1900245. (B06, A01, B03)

2018

Rottensteiner-Brandl U, Detsch R, Sarker B, Lingens L, Kohn K, Kneser U, Bosserhoff AK, Horch RE, Boccaccini AR, Arkudas A, Encapsulation of Rat Bone Marrow Derived Mesenchymal Stem Cells in Alginate Dialdehyde/Gelatin Microbeads with and without Nanoscaled Bioactive Glass for In Vivo Bone Tissue Engineering, Materials (Basel) 11(10) (2018) 1880. (C04, A01, C03)

Ruther F, Distler T, Boccaccini AR, Detsch R, Biofabrication of vessel-like structures with alginate di-aldehyde-gelatin (ADA-GEL) bioink, J. Mater. Sci.: Mater. Med. 30(1) (2018) 8. (B06, A01)

Steiner D, Lingens L, Fischer L, Kohn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier JP, Horch RE, Arkudas A, Encapsulation of Mesenchymal Stem Cells Improves Vascularization of Alginate-Based Scaffolds, Tissue Eng Part A 24(17-18) (2018) 1320-1331. (C03, C04, A01, B06, B03) Front Cover for Tissue Engineering Part A

2022

David Böhringer, Lars Bischof, Tina Czerwinski, Mar Cóndor, Sibel Kara, Anja Lux, Silvia Budday, Richard Gerum, Ben Fabry, Christoph Mark
SFB/TRR 225 Project A01: Traction forces of migrating immune cells
Symposium “Biofabrication meets Infection” Würzburg on 25-28. September 2022              Z02

2021

Genc H, Hazur J, Karakaya E, Dietel B, Bider F, Groll J, Alexiou C, Boccaccini AR, Detsch R, Cicha I (2021)
Alginate di-Aldehyde-Induced Oxidative Stress in Endothelial Cells and Fibroblasts: Cell-specific Responses
31st Annual Conference of the European Society for Biomaterials (ESB 2021), 5 to 9 September 2021              (A01, B02, B06)

Hazur J, Grummel N, Schubert DW, Fabry B, Boccaccini AR (2021)
Cell proliferation and morphology of NIH/3T3 cells are influenced by stress-relaxation behavior which can be modified by pre-crosslinking in alginate-gelatin-based hydrogels
31st Annual Conference of the European Society for Biomaterials (ESB 2021), 5 to 9 September 2021 (virtual) (A01)

Schmid R, Schmidt SK, Detsch R, Horder H, Blunk T, Schrüfer S, Schubert DW, Fischer L, Thievessen I, Heltmann-Meyer S, Steiner D, Schneidereit D, Friedrich O, Grüneboom A, Amouei H, Wajant H, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A (2021)
A new printable alginate / hyaluronic acid / gelatin hydrogel suitable for biofabrication of in vitro and in vivo metastatic melanoma models
31st Annual Conference of the European Society for Biomaterials (ESB 2021), 5 to 9 September 2021 (C03, A01, A07, B06, B08, C02, C04)

2020

Karakya E, Fischer L, Hazur J, Boccaccini ARB, Thievessen I, Detsch R (2020)
Strategies to evaluate alginate based bioinks applyingextrusion printing for biofabrication
AMMM – Additive Manufacturing Meets Medicine 2020, 9 – 11 September 2020 – Web conference

Hazur J, Geske M, Esper L, Boccaccini  AR (2020)
Tailoring mechanical properties and degradation behavior of alginate dialdehyde-gelatin (ADA-GEL) hydrogels
5th Bioinspired Materials 2020 Conference, 16 – 19 March 2020 – Web conference

2019

Hazur J, Kaschta J, Schubert DW, Detsch R, Boccaccini AR (2019)
Rheologische Charakterisierung und 3D Biodrucken von vorvernetzten Alginat Biotinten
WerkstoffWoche Dresden; September 18 to 20, 2019 (Dresden, Germany)

Detsch R, Hazur J, Karakaya E, Kuth S, Heid S, Boccaccini AR (2019)
Evaluating three different extrusion-based bioprinting systems using cell-laden alginate-based bioinks
30th Annual Conference of the European Society for Biomaterials in tandem with the 26thAnnual Conference of the German Society for Biomaterials (DGBM); September 9 to 13, 2019 (Dresden, Germany)

2018

Boccaccini AR (2018)
Bioinks containing reactive fillers in biofabrication approaches
Invited presentation at West Pomeranian University of Technology, 22 November 2018 (Szczecin, Poland)

Boccaccini AR (2018)
Bioactive Materials and Biofabrication for Biomedical Applications: Progress and Challenges
Invited speaker at Scientific Workshop 2018, Rostock University Medicine (Universitätsmedizin Rostock), 16 November 2018 (Rostock, Germany)

Boccaccini AR (2018)
Bioactive materials and biofabrication for tissue engineering: achievements and challenges”
Invited presentation at Polytechnic School (Escuela Politecnica Superior, EPS), University of Seville, 31st October 2018 (Seville, Spain).

Boccaccini AR (2018)
Development of composite bioinks incorporating bioreactive inorganic particles
Invited presentation at: International Conference on Biofabrication (ISBF) 2018, 28-31 October 2018 (Würzburg, Germany).

Boccaccini AR (2018)
Biofabrication with alginate di-aldehyde / gelatin (ADA/GEL) hydrogels: progress, applications and challenges
Oral presentation at: Biomaterials and Novel Technologies for Healthcare, 2nd International Biennial Conference BioMaH, Frascati, 8-11 October, 2018 (Rome, Italy).

Boccaccini AR (2018)
Bioactive materials and biofabrication for tissue engineering applications
Invited seminar at: CONICET Laboratory of Integration of Cellular Signals at the Institute for Histology and Embryology, Faculty of Medicine, National University of Cuyo (UNCUYO), 27th August 2018 (Mendoza, Argentina).

Boccaccini AR (2018)
Bioactive materials and biofabrication for bone and soft tissue engineering
Invited lecture at: Justus-Liebig-University Giessen, Medical School, 19th July 2018 (Giessen, Germany).

Boccaccini AR (2018)
Bioactive materials and biofabrication for tissue engineering: progress and challenges
Invited speaker at: Junior EUROMAT 2018 Conference, 8-12 July 2018 (Budapest, Hungary).

Boccaccini AR (2018)
Enhancing alginate based bioinks for biofabrication: the composites approach
Invited speaker at: 1st TERMIS-EU Workshop on “3D Printing in Musculoskeletal Tissue Engineering”, 22-23 March 2018 (Warsaw, Poland).

Boccaccini AR (2018)
Bioactive materials and biofabrication approaches for hard tissue regeneration
Invited speaker at: 2nd Sino-German Symposium on Reconstruction and Repair of Musculoskeletal Tissues, Mainz University Medical Center, 13-14 March 2018 (Mainz, Germany).

2023

Jonas Röder, Emine Karakaya, Rainer Detsch & Aldo R Boccaccini
Development of Methylacrylated Alginate Bioinks for Drop-on-Demand Printing
FEMS Euromat 2023, Frankfurt am Main on 03-07. September 2023

2022

David Böhringer, Lars Bischof, Tina Czerwinski, Mar Cóndor, Sibel Kara, Anja Lux, Silvia Budday, Richard Gerum, Ben Fabry, Christoph Mark
SFB/TRR 225 Project A01: Traction forces of migrating immune cells
Symposium “Biofabrication meets Infection” Würzburg on 25-28. September 2022                       A01

Rafael Schmid, Sonja K. Schmidt, Rainer Detsch, Hannes Horder, Torsten Blunk, Stefan Schrüfer, Dirk W. Schubert, Lena Fischer, Ingo Thievessen, Stefanie Heltmann-Meyer, Dominik Steiner, Dominik Schneidereit, Oliver Friedrich, Anika Grüneboom, Hanna Amouei, Harald Wajant, Raymund E. Horch, Anja K. Bosserhoff, Andreas Arkudas, Annika Kengelbach-Weigand
A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo
Metastatic Melanoma Models TERMIS EU 2022               C03 and A01, A07, B06, B08, C02, C04

2021

2020

Schneidereit D, Distler T, Meinert C, Carlé B, Detsch R, Schürmann S, Hutmacher D, Boccaccini AR, Friedrich O (2020)
Multiphoton Microscopy: A powerful tool to reveal cellular organization and morphology within bioengineered constructs in 3D
5th Bioinspired Materials 2020 Conference, 16 – 19 March 2020 – Web conference

2019

Karakaya E, Hazur J, Teßmar J, Boccaccini AR, Detsch R(2019)
How to Determine a Suitable Sodium Alginate for the Fabrication of Standardized Alginatedialdehyde-Gelatin crosslinked Hydrogels in Biofabrication Approaches?
Annual Conference of the International Society for Biofabrication (ISBF), 20-22 October 2019 (Columbus, Ohio, USA)

Hazur J, Kaschta J, Schubert DW, Detsch R, Boccaccini AR (2019)
Rheological examintation and 3D bioprinting of internally pre-crosslinked alginate bioinks
30th Annual Conference of the European Society for Biomaterials in tandem with the 26thAnnual Conference of the German Society for Biomaterials (DGBM); September 9 to 13, 2019 (Dresden, Germany)

2018

Detsch R, Boccaccini AR (2018)
Advances in Biomaterials for Biofabrication: 3D Printing with Bioinks
“Tag der Technischen Fakultät” of the FAU Erlangen, 16 November 2018 (Erlangen, Germany)

Elham Mirzahossein

Previous academic education: Master of Physics in Sharif University of Technology
Academic Advisor within SFB TRR225: Prof. Dr. Ben Fabry
Location: Friedrich-Alexander University of Erlangen-Nuremberg, Department of Physics
Topic of thesis: Adhesive functionalized and controlled degrading alginate-based hydrogels
Main techniques and methodologies to be used: 3D- printer, fluorescent microscopy, microfluidic and micro-indentor

Contact: Elham.mirzahossein@fau.de

Jonas Hazur

Previous academic education: Sc. in Nanotechnology, Sc. in Materials Science: “Characterization of rheological behavior and processability in additive manufacturing of different medical grade alginate gel systems“
Academic Advisor within SFB TRR225: Prof. Dr.-Ing. habil. Aldo R. Boccaccini, Dr.-Ing. Rainer Detsch (technical advisor)
Location: Friedrich-Alexander University of Erlangen-Nuremberg, Institute of Biomaterials
Topic of thesis: Systematical investigation of adhesive functionalized and controlled degrading alginate based hydrogels
Main techniques and methodologies to be used: Bioplotting, chemical and physical modification, cell culture, degradation studies, spectroscopy, microscopy, rheology

Contact: Jonas.hazur@fau.de

Huijun Zhang

Previous academic education: M. Sc. Polymer Chemistry
Academic Advisor within SFB TRR225: Prof. Dr. Ben Fabry
Location: Friedrich-Alexander University of Erlangen-Nuremberg, Biophysics group, Center for Medical Physics and Technology
Topic of thesis: Development and characterization of organic-inorganic hybrids and composites for tissue engineering
Main techniques and methodologies to be used: Bioplotting, chemical and physical modification, spectroscopy, microscopy, rheology, degradation studies, cell migration assays
Contact: huijun.zhang@fau.de

Sebastian Richter

Previous academic education: Dipl. Ing.
Academic Advisor within SFB TRR225: Prof. Dr. Ben Fabry
Location: Friedrich-Alexander University of Erlangen-Nuremberg, LS f Biophysik
Topic of thesis:
Main techniques and methodologies to be used: Software- & Hardware-Development / Mashine Learning / Computer Vision

Contact: srichter@biomed.uni-erlangen.de

Prof. Dr. Aldo R. Boccaccini

  • Member of the Advisory Committee, Department of International Scientific Cooperation, Ministry of Science and Technology of Argentina
  • Expert Reviewer for funding agencies, e.g. Swiss National Science Foundation, Deutsche Forschungsgemeinschaft (DFG), UK EPSRC, US-Israel Binational Science Foundation, etc.
  • Founder and Chair of ECI’s International Conference Series on “Electrophoretic Deposition”.
  • Editor-in-Chief, Materials Letters (Elsevier)
    Founder and Editor-in-Chief, journal: Biomedical Glasses (De Gruyter)
  • Elected member for the Council of the European Society for Biomaterials
  • Member of the Editorial Board of the following international journals: “Advances in Applied Ceramics”, “Journal of Biomaterials Applications”, “Adv. Eng. Mater.”, “J. Tissue Engineering and Regenerative Medicine” (Wiley), “Interceram”, “Recent Patents on Engineering”, “Recent Patents on Materials Science, “J. Mater. Proc. Technol.”, “Adv. Eng. Materials “J. Mater. Sci.”, “Int. Mater. Reviews”, “Scientific Reports” (Nature Publishing Group)

Prof. Dr. Ben Fabry

  • Coordinator of the “Physics in Medicine” study focus
  • Managing Director, Centre for Medical Physics and Technology, University of Erlangen-Nuremberg
  • Editorial Board, Cellular and Molecular Bioengineering
  • Advisory Board, International Max-Planck Research School Erlangen
  • Member of the management of the Central Institute for Medical Technology (ZIMT) as representative of the Faculty of Natural Sciences
  • Chairman of the examination board of the “Integrated Life Sciences” degree programme
  • Editorial Board, Biomechanics and Modeling in Mechanobiology
  • Associate Editor, Scientific Reports
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