C04 | Biofabrication of cellularized and by the AV-loop vascularized tissue container for the transplantation of cells producing therapeutic proteins
Aim of the project is the development of a broadly applicable transplantable tissue container which enables the in vivo production of recombinant therapeutic proteins, e.g. antibodies. For this a container shell will be filled with two cell doted matrix cylinders structured with tubes. The cylinders contains a bed in which a AV loop can be placed which sprouts into the tube system to ensure the vascularization of the container and producer cell maintenance. Container vascularization in the bioreactor, container immune tolerance and container evaluation in pre-clinical models are the subjects of future funding periods.
Peddi A, Steiner D, Weigand A, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier JP, Horch RE, Arkudas A. (2018) Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds, The 10th EPSRC Meeting, 23 – 25 August 2018 (Hamburg, Germany)
Heltmann-Meyer S, Steiner D, Lang G, Winkler S, Fischer L, Fey T, Greil P, Scheibel T, Horch RE, Arkudas A. (2018) Intrinsic Vascularization of Recombinant eADF4(C16) Spider Silk fibrous matrices in the Arteriovenous Loop Model, 10th EPSRC Meeting, 23 – 25 August 2018 (Hamburg, Germany)