B02 | Pre-endothelialized perfusable microvascular networks for biofabrication of standardized in vitro tissue models.
The aim of this project is biofabrication of perfusable and fully pre-endothelialized microvascular networks, which will be produced by MEW of thermosensitive polyoxazolines and subsequently embedded in cell-containing hydrogels. Particular focus will be placed on biocompatibility of hydrogels (bioinks) and selection of geometries compatible with microscopic techniques. As microvascular endothelium provides an important barrier and functional regulation of physiological processes, we will extensively investigate the efficacy of colonization and network functionality. In longer perspective, these models will be adapted for tissue-specific and tumor research.