B02 | Pre-endothelialized perfusable microvascular networks for biofabrication of standardized in vitro tissue models.

The aim of this project is biofabrication of perfusable and fully pre-endothelialized microvascular networks, which will be produced by MEW of thermosensitive polyoxazolines and subsequently embedded in cell-containing hydrogels. Particular focus will be placed on biocompatibility of hydrogels (bioinks) and selection of geometries compatible with microscopic techniques. As microvascular endothelium provides an important barrier and functional regulation of physiological processes, we will extensively investigate the efficacy of colonization and network functionality. In longer perspective, these models will be adapted for tissue-specific and tumor research.

PD Dr. Iwona Cicha
Prof. Dr. Jürgen Groll

Hatice Genc

Previous academic education: Master thesis: Anti-angiogenic drug development, PhD course: Nanoparticles for Photodynamic Cancer Therapy, Research projects: Nanoparticle Biocompatibility
Academic Advisor within SFB TRR225: PD Dr. Iwona Cicha
Location: University Hospital Erlangen, Section of Experimental Oncology and Nanomedicine
Topic of thesis: Pre-endothelialized perfusable microvascular networks for biofabrication of standardized in vitro tissue models
Main techniques and methodologies to be used: Cell Colonization, Cell response to hydrogels, Biocompatibility, Functionality of microvascular networks, Angiogenesis

Contact: hatice.genc@uk-erlangen.de

Matthias Ryma

Previous academic education: 10/2009-12/2014:      Studies of biology,  01/2015-07/2015:  Prüfhiwi at TERM – Würzburg, Since 10/2015:  PhD-Thesis at FMZ, Würzburg
Academic Advisor within SFB TRR225: Prof. Dr. Jürgen Groll
Location: Department of functional material in medicine and dentistry, University of Würzburg
Topic of thesis: Pre-endothelialized perfusable microvascular vesselsystems for biofabrication of standardized tissue models
Main techniques and methodologies to be used: Melt Electrowriting, 3-dimensional cell culture

Contact: matthias.ryma@fmz.uni-wuerzburg.de