B02 | Pre-endothelialized perfusable microvascular networks for biofabrication of standardized in vitro tissue models.

The aim of this project is biofabrication of perfusable and fully pre-endothelialized microvascular networks, which will be produced by MEW of thermosensitive polyoxazolines and subsequently embedded in cell-containing hydrogels. Particular focus will be placed on biocompatibility of hydrogels (bioinks) and selection of geometries compatible with microscopic techniques. As microvascular endothelium provides an important barrier and functional regulation of physiological processes, we will extensively investigate the efficacy of colonization and network functionality. In longer perspective, these models will be adapted for tissue-specific and tumor research.

PD Dr. Iwona Cicha
Prof. Dr. Jürgen Groll

Hatice Genc

Previous academic education: Master thesis: Anti-angiogenic drug development, PhD course: Nanoparticles for Photodynamic Cancer Therapy, Research projects: Nanoparticle Biocompatibility
Academic Advisor within SFB TRR225: PD Dr. Iwona Cicha
Location: University Hospital Erlangen, Section of Experimental Oncology and Nanomedicine
Topic of thesis: Pre-endothelialized perfusable microvascular networks for biofabrication of standardized in vitro tissue models
Main techniques and methodologies to be used: Cell Colonization, Cell response to hydrogels, Biocompatibility, Functionality of microvascular networks, Angiogenesis

Contact: hatice.genc@uk-erlangen.de

Ali Nadernezhad

Previous academic education: Master of Science in Biomedical Engineering (Biomaterials)
Academic Advisor within SFB TRR225: Prof. Dr. Jürgen Groll
Location: Department of functional material in medicine and dentistry, University of Würzburg
Topic of thesis: Pre-endothelialized perfusable microvascular vesselsystems for biofabrication of standardized tissue models
Main techniques and methodologies to be used: Melt Electrowriting, 3D cell culture

Contact: ali.nadernezhad@fmz.uni-wuerzburg.de

Matthias Ryma

Previous academic education: 10/2009-12/2014: Studies of biology,  01/2015-07/2015:  Prüfhiwi at TERM – Würzburg, Since 10/2015:  PhD-Thesis at FMZ, Würzburg
Academic Advisor within SFB TRR225: Prof. Dr. Jürgen Groll
Location: Department of functional material in medicine and dentistry, University of Würzburg
Topic of thesis: Pre-endothelialized perfusable microvascular vesselsystems for biofabrication of standardized tissue models
Main techniques and methodologies to be used: Melt Electrowriting, 3-dimensional cell culture

Contact: matthias.ryma@fmz.uni-wuerzburg.de

Groll J (2018) Biofabrication research at FMZ: from solution electrospun meshes to thiol-ene cross-linked hydrogel-bioinks, International Conference on Additive Manufacturing and Biomanufacturing,  2-4 December 2018 (Beijing, China)

Groll J (2018) Bio-ink development for Biofabrication, International Conference on Emerging Healthcare Materials, 15-16 November 2018 (Seoul, South-Korea)

Groll J (2018) SFB/TRR 225: From the Fundamentals of Biofabrication to Functional Tissue Models, International Conference on Biofabrication (ISBF) 2018, 28-31 October 2018 (Würzburg, Germany)

Groll J (2018) Hydrogels as Bioinks for Biofabrication, MSE conference, 26 – 28 September 2018, (Darmstadt, Germany)

Groll J (2018) Melt Electro Writing at the Department of Functional Materials in Medicine and Dentistry, Annual Meeting of the European Society for Biomaterials,  10 – 13 September2018 (Maastricht, Netherlands)

Groll J (2018) Biofabrication: Status of the field and translational perspective, 3D-BioNET-working-event,  18 July 2018 (Freiburg im Breisgau, Germany)

Groll J (2018) Biotinten: 3D-Druckbare Hydrogele als Schlüssel zum BioPrinting, Materialinnovationen 2018 – Vom Material zur Innovation, Konferenz zur Materialforschung des BMBF, 4. – 6. June 2018, (München, Germany)

Groll J (2018) Hydrogels as “Bio-inks” for Biofabrication, 2nd Theodore von Kármán – Discussion Conference on Materials for Life: Bioinspired and Biomimetic Hydrogels, 15 – 18 April 2018, (Bensberg, Germany).

Groll J (2018) Bioinks: Concepts, Rheological Considerations and Recent Trends, TERMIS workshop on 3D Printing in Musculoskeletal Tissue Engineering: Bioprinting in Action, 23 March 2018 (Warsaw, Poland)

Groll J (2018) 3D-Druckbare Hydrogele als Tinten für die Biofabrikation, Thüringer Biomaterial Kolloquium, 13. – 15. March 2018 (Zeulenroda, Germany)