A06 | Cell-loaded microgels as mechanical protection and controlled microenvironment for cells in bioinks

Aim of this project is the generation of cell-loaded microgels with uniform size and their establishment as additive for bioinks. The microgels shall on the one side act as mechanical protection from shear-forces during printing and thereby extend the biofabrication window towards bioinks with higher viscosity and towards higher shear forces. In addition to that, biochemical functionalization and adjusting microgel degradability shall be used to tailor the microenvironment of the encapsulated cells and control their behavior. Prospectively, this project aims at establishing suspensions of cell-loaded microgels as bioink especially for the simultaneous printing of different cell types.

Prof. Dr. Stephan Förster
Prof. Dr. Jürgen Groll

 

Ilona Paulus

Previous academic education: Master of Science in chemistry
Academic Advisor within SFB TRR225: Prof. Dr. Jürgen Groll
Location: University of Würzburg, Department for functional materials in medicine and dentistry
Topic of thesis: Multifunctional POx-based building blocks for bioinks
Main techniques and methodologies to be used: Chemical synthesis, Microfluidic, 3D-Printing

Contact: ilona.paulus@fmz.uni-wuerzburg.de

Benjamin Reineke

Previous academic education: Polymer Science M.Sc. @ Uni Bayreuth
Academic Advisor within SFB TRR225: Prof. Dr. Stephan Förster
Location: Forschungszentrum Jülich
Topic of thesis: Microfluidic chips for the encapsulation of cells
Main techniques and methodologies to be used: Microfluidic chip design, soft lithography, preparation of colloids using microfluidics

Contact: b.reineke@fz-juelich.de