A08 | Vascular supply for 3D tissue based on shape-changing polymers and recombinant spider silk

The aim of this project is the fabrication of hierarchically structured tissues with integrated fiber-based structures, which give the matrix anisotropic properties for directed cell growth, as well as tubular elements for the supply of nutrients and oxygen. To implement the project, various manufacturing methods such as 4D biofabrication approaches and established 3D printing and fiber spinning processes will be combined. The integrated tubular structures should also provide a basis for a later vascularization of the constructs after tissue maturation.

Prof. Dr. Leonid Ionov
Prof. Dr. Thomas Scheibel

Christina Heinritz

Previous academic education: M.Sc. Biochemistry & Molecular Biology, B.Sc. Biochemistry, University of Bayreuth
Academic Advisor within SFB/TRR225: Prof. Dr. Thomas Scheibel
Location: University of Bayreuth, Department of Biomaterials
Topic of thesis: Vascularization of 3D tissue scaffolds based on shape-changing biopolymers and recombinant spider silk
Main techniques and methodologies to be used: Electrospinning, protein processing, bioprinting, 3D cell culture, cell/molecular & mechanical analysis

Contact: christina.heinritz@bm.uni-bayreuth.de 

Saskia Roth

Previous academic education:
Academic Advisor within SFB/TRR225: Prof. Dr. Leonid Ionov
Location: University of Bayreuth, Faculty of Engineering Science – Biofabrication
Topic of thesis: Fabrication and characterization of hierarchically organized vascular structures
Main techniques and methodologies to be used: Melt electrowriting, 4D bioprinting, cell culture, biomolecular analysis, immunohistochemistry

Contact: Saskia.Roth@uni-bayreuth.de

Mairon Trujillo Miranda

Previous academic education: Master of Science in Biofabrication
Academic Advisor within SFB/TRR225: Prof. Dr. Leonid Ionov
Location: University of Bayreuth, Faculty of Engineering Science – Biofabrication
Topic of thesis: Fabrication of Vascular Networks based on Shape-Changing Polymers within 3D printed hydrogels
Main techniques and methodologies to be used: Electrospinning, self-folding, cell culture, mechanical tests, microscopy, bioreactor.

Contact: Mairon.Trujillo-Miranda@uni-bayreuth.de