Skip to main content

A08 | Vascular supply for 3D tissue based on shape-changing polymers and recombinant spider silk

The aim of this project is the fabrication of hierarchically structured tissues with integrated fiber-based structures, which give the matrix anisotropic properties for directed cell growth, as well as tubular elements for the supply of nutrients and oxygen. To implement the project, various manufacturing methods such as 4D biofabrication approaches and established 3D printing and fiber spinning processes will be combined. The integrated tubular structures should also provide a basis for a later vascularization of the constructs after tissue maturation.

Prof. Dr. Leonid Ionov
Prof. Dr. Thomas Scheibel

Christina Heinritz

Previous academic education: M.Sc. Biochemistry & Molecular Biology, B.Sc. Biochemistry, University of Bayreuth
Academic Advisor within SFB/TRR225: Prof. Dr. Thomas Scheibel
Location: University of Bayreuth, Department of Biomaterials
Topic of thesis: Vascularization of 3D tissue scaffolds based on shape-changing biopolymers and recombinant spider silk
Main techniques and methodologies to be used: Electrospinning, protein processing, bioprinting, 3D cell culture, cell/molecular & mechanical analysis

Contact: christina.heinritz@uni-bayreuth.de 

Saskia Roth

Previous academic education:
Academic Advisor within SFB/TRR225: Prof. Dr. Leonid Ionov
Location: University of Bayreuth, Faculty of Engineering Science – Biofabrication
Topic of thesis: Fabrication and characterization of hierarchically organized vascular structures
Main techniques and methodologies to be used: Melt electrowriting, 4D bioprinting, cell culture, biomolecular analysis, immunohistochemistry

Contact: Saskia.Roth@uni-bayreuth.de

2024

Koeck KS, Trossmann VT, Scheibel T. 3D-Printed and Recombinant Spider Silk Particle Reinforced Collagen Composite Scaffolds for Soft Tissue Engineering. Adv. Funct. Mater. doi: 10.1002/adfm.202407760 (2024). (A08, C01)

Sprenger L, Lu H-H, Trippmacher S, Mansfeld U, Milkin P, Ionov L, Papastavrou G, Boccaccini AR, Salehi S. Composite Alginate Dialdehyde-Gelatin (ADA-GEL) Hydrogel Containing Short Ribbon-Shaped Fillers for Skeletal Muscle Tissue Biofabrication. ACS Applied Materials & Interfaces doi: 10.1021/acsami.4c10751 (2024). (B03, B07, A08)

2023

Hosseinabadi HG, Biswas A, Bhusal A, Yousefinejad A, Lall A, Zimmermann W-H, Miri AK, Ionov L. 4D-Printable Photocrosslinkable Polyurethane-Based Inks for Tissue Scaffold and Actuator Applications. Small, doi: 10.1002/smll.202306387 (2023). (A08)

Heinritz C, Ng XJ, Scheibel T, Bio‐inspired Protein‐Based and Activatable Adhesion Systems, Advanced Functional Materials doi:10.1002/adfm.202303609  (2023). (A08, C01)

Kitana W, Levario-Diaz V, Cavalcanti-Adam EA, Ionov L. Biofabrication of Composite Bioink-Nanofiber Constructs: Effect of Rheological Properties of Bioinks on 3D (Bio)Printing and Cells Interaction with Aligned Touch Spun Nanofibers. Adv. Healthcare Mater., doi: 10.1002/adhm.202303343 (2023). (A08)

Trossmann VT, Lentz S, Scheibel T, Factors Influencing Properties of Spider Silk Coatings and Their Interactions within a Biological Environment, Journal of Functional Biomaterials 14(8) (2023). (A08, C01)

2022

Kitana W, Apsite I, Hazur J, Boccaccini AR, Ionov L, 4D Biofabrication of T‐Shaped Vascular Bifurcation, Advanced Materials Technologies doi:10.1002/admt.202200429  (2022). (A01, A08)

2022

Scheibel, Thomas Invited speaker: Bioproscale, Berlin, 29.03.2022

Scheibel, Thomas Invited speaker: 3DMM2O, Schöntal Monastry, 07.04.2022

Scheibel, Thomas Invited speaker: ASBTE, Melbourne, 20.04.2022

Scheibel, Thomas Invited speaker: ICRI-BioM lecture, 10.06.2022

Scheibel, Thomas Invited speaker: CIMTEC, Perugia 22.06.2022

Scheibel, Thomas Invited speaker: Bioinspired Materials Andermatt, 09.08.2022

Scheibel, Thomas Invited speaker: Monash Biofabrication lecture, 25.08.2022

Scheibel, Thomas Invited speaker: CRC 1459 Summer School Biofabrication, 19.09.2022

Scheibel, Thomas Invited speaker: 3rd International Workshop on Insect Bio-inspired Technologies 18.11.2022

Leonid Ionov (Keynote)
Possibilities and limitations of 4D biofabrication NTB_005
Meeting of The International Society for Biofabrication 2022, Montecatini Terme (Italy) on 25-28. September 2022 A08

Sahar Salehi, K.S. Koeck, Martin Humenik, Thomas Scheibel
Continuous non-crosslinked collagen fibers as building blocks of the musculotendinous junction
MSE congress, B03, C01, A08

2024

Christina Heinritz, Andreas Arkudas, Tobias Fey, Laura Fischer, Peter Greil, Stefanie Heltmann-Meyer, Raymund Horch, Gregor Lang, Dominik Steiner, Vanessa Trossmann, Sophie Winkler, Thomas Scheibel
Recombinant spider silk for vascularized engineered tissue
EMBO workshop: Building networks 2024: engineering in vascular biology on 5th June 2024 (A08)

2022

Saskia Roth, Christina Heinritz, Leonid Ionov, Thomas Scheibel
SFB/TRR 225 Project A08: Vascular supply for 3D tissue based on shape-changing polymers and recombinant spider silk
Symposium “Biofabrication meets Infection” Würzburg on 25-28- September 2022     A08

Mairon Trujillo Miranda

Previous academic education: Master of Science in Biofabrication
Academic Advisor within SFB/TRR225: Prof. Dr. Leonid Ionov
Location: University of Bayreuth, Faculty of Engineering Science – Biofabrication
Topic of thesis: Fabrication of Vascular Networks based on Shape-Changing Polymers within 3D printed hydrogels
Main techniques and methodologies to be used: Electrospinning, self-folding, cell culture, mechanical tests, microscopy, bioreactor.

Contact: Mairon.Trujillo-Miranda@uni-bayreuth.de

„Kombiniertes 3D-Druck-Faserspinnen“, inventor: Leonid Ionov (A08), applicant: UBT

Prof. Dr. Thomas Scheibel

Prof. Dr. Leonid Ionov