C03 | Analysis of tumor dormancy and progression in biofabricated and in vivo vascularized 3D models
Using biofabrication methods a 3D tumor model will be developed, serving for the investigation of different aspects of tumor progression in a controlled manner both in vitro and in the vascularized in vivo AV loop model. In particular, with the establishment of a such highly-defined biofabricated melanoma tumor model essential tumor properties, such as tumor dormancy and metastasis, but also the influence of the tumor microenvironment can be analyzed and specifically modified and controlled.
Rottensteiner-Brandl U, Detsch R, Sarker B, Lingens L, Köhn K, Kneser U, Bosserhoff AK, Horch RE, Boccaccini AR, Arkudas A. (2018) Encapsulation of Rat Bone Marrow Derived Mesenchymal Stem Cells in Alginate Dialdehyde/Gelatin Microbeads with and without Nanoscaled Bioactive Glass for In Vivo Bone Tissue Engineering. Materials (Basel). 2018 Oct 1;11(10). pii: E1880. doi: 10.3390/ma11101880.
An R, Schmid R, Klausing A, Robering JW, Weber M, Bäuerle T, Detsch R, Boccaccini AR, Horch RE, Boos AM, Weigand A. (2018) Proangiogenic effects of tumor cells on endothelial progenitor cells vary with tumor type in an in vitro and in vivo rat model. FASEB J. 2018 Oct;32(10):5587-5601. doi: 10.1096/fj.201800135RR. Epub 2018 May 10.
Steiner D, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier J, Horch RE, Arkudas A. (2018) Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds. Tissue Eng Part A. 2018 Mar 20. doi: 10.1089/ten.TEA.2017.0496. Front Cover for Tissue Engineering Part A