C03 | Analysis of tumor dormancy and progression in biofabricated and in vivo vascularized 3D models

Using biofabrication methods a 3D tumor model will be developed, serving for the investigation of different aspects of tumor progression in a controlled manner both in vitro and in the vascularized in vivo AV loop model. In particular, with the establishment of a such highly-defined biofabricated melanoma tumor model essential tumor properties, such as tumor dormancy and metastasis, but also the influence of the tumor microenvironment can be analyzed and specifically modified and controlled.

Prof. Dr. Andreas Arkudas
Prof. Dr. Anja Boßerhoff
Dr. Annika Weigand

Publications:

Rottensteiner-Brandl U, Detsch R, Sarker B, Lingens L, Köhn K, Kneser U, Bosserhoff AK, Horch RE, Boccaccini AR, Arkudas A. (2018) Encapsulation of Rat Bone Marrow Derived Mesenchymal Stem Cells in Alginate Dialdehyde/Gelatin Microbeads with and without Nanoscaled Bioactive Glass for In Vivo Bone Tissue Engineering. Materials (Basel). 2018 Oct 1;11(10). pii: E1880. doi: 10.3390/ma11101880.

An R, Schmid R, Klausing A, Robering JW, Weber M, Bäuerle T, Detsch R, Boccaccini AR, Horch RE, Boos AM, Weigand A. (2018) Proangiogenic effects of tumor cells on endothelial progenitor cells vary with tumor type in an in vitro and in vivo rat model. FASEB J. 2018 Oct;32(10):5587-5601. doi: 10.1096/fj.201800135RR. Epub 2018 May 10.

Steiner D, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier J, Horch RE, Arkudas A. (2018) Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds. Tissue Eng Part A. 2018 Mar 20. doi: 10.1089/ten.TEA.2017.0496.      Front Cover for Tissue Engineering Part A

Sonja Schmidt

Previous academic education: Master of Science
Academic Advisor within SFB TRR225: Prof. Dr. Anja Boßerhoff
Location: FAU Erlangen-Nürnberg, Department for Biochemistry and Molecular Medicine
Topic of thesis: Analysis of tumor dormancy and progression in biofabricated and in vivo vascularized 3D models
Main techniques and methodologies to be used: Analysis of cell behavior & signaling pathways (cell culture, fluorescence microscopy, qPCR, Western Blot, …)

Contact: sonja.s.schmidt@fau.de

Rafael Schmid

Previous academic education: Master of Tissue Engineering and Regenerative Medicine
Academic Advisor within SFB TRR225: Prof. Dr. Andreas Arkudas, Dr. Annika Weigand
Location: University Hospital of Erlangen, Department of Plastic and Hand Surgery
Topic of thesis: Analysis of tumor dormancy and progression in biofabricated and vascularized in vivo 3D models
Main techniques and methodologies to be used: cell culture, cell culture assays, (live cell) microscopy, in vivo AV loop, in vivo 3D imaging (immuno)histology, gene expression

Contact: rafael.schmid@uk-erlangen.de

Ajay Peddi

Previous academic education: Master in Biomedical Engineering, Martin Luther University Halle, Germany Effects of Fresh Blood Versus Old Blood (stored) on Hepatocyte Viability, Proliferation, Gene Expression; Comparison of the Effects in Hepatocyte 2D and 3D Cell Culture Models
Bachelor of Pharmacy, Rajeev Gandhi University of Health Sciences, India
Academic Advisor within SFB TRR225: Prof. Dr. Andreas Arkudas, Dr. Annika Weigand
Location: University Hospital of Erlangen, Department of Plastic and Hand Surgery
Topic of thesis: Analysis of tumor dormancy and progression in biofabricated and vascularized in vivo 3D models
Main techniques and methodologies to be used: cell culture, cell culture assays, (live cell) microscopy, in vivo AV loop, in vivo 3D imaging (immuno)histology, gene expression

Contact: Ajay.Peddi@uk-erlangen.de