C01 | Biofabrication of heart substitute tissue based on bioink from spider silk proteins

Heart diseases are a major socioeconomic burden. Despite considerable progress in the prevention and minimization of heart damage, the prevalence of heart insufficiency increases continuously. The aim of this subproject is the reproducible production of human cardiac substitute tissue based on a scaffold with adjustable mechanical properties from spider silk bioink and cardiac cells using 3D printing technology. The long-term goal is the treatment of heart diseases.

Prof. Dr. Felix Engel
Prof. Dr. Thomas Scheibel

Publications:

Roshanbinfar K, Vogt L, Greber B, Diecke S, Boccaccini A, Scheibel T, Engel FB. (2018) Electroconductive Biohybrid Hydrogel for Enhanced Maturation and Beating Properties of Engineered Cardiac Tissues, Adv Funct Mater, 2018 Sep 06. doi: 10.1002/adfm.201803951

 Presentations:

Engel FB. (2018) New scaffolds for cardiac repair, ESC Congress 2018 (European Cardiac Society) 25 – August 2018 (Munich, Germany)

Tilman Esser

Previous academic education: M.Sc (Cardiovascular Science), B.Sc. (Molecular Medicine), University of Göttingen
Academic Advisor within SFB TRR225: Prof. Dr. Felix Engel
Location: Universitätsklinikum Erlangen, Nephropathology
Topic of thesis: Biofabrication of Silk-based Artificial Heart Tissue
Main techniques and methodologies to be used: Stem Cell Culture, Cardiac Differentiation, Bioprinting, Cell & Molecular Analysis

Contact: tilman.esser@uk-erlangen.de

Vanessa Trossmann

Previous academic education: Master-thesis
Academic Advisor within SFB TRR225: Prof. Dr. Thomas Scheibel
Location: University of Bayreuth, Chair of Biomaterials
Topic of thesis: Recombinant spider silk proteins with designed cell-substrate-interaction for biomedical applications
Main techniques and methodologies to be used: Cloning, recombinant protein expression and purification, protein characterization, protein processing (films, bioinks), 3D-Bioprinting, Cell culture

Contact: vanessa.trossmann@bm.uni-bayreuth.de

Annika Döbl

Previous academic education: Master-thesis
Academic Advisor within SFB TRR225: Prof. Dr. Thomas Scheibel
Location: University of Bayreuth, Chair of Biomaterials
Topic of thesis: Spider silk-based 3D cultivation of tumor cells as in vitro model for cancer research
Main techniques and methodologies to be used: 3D printing/bioprinting, cell culture, protein processing, chemical protein modification

Contact: annika.doebl@bm.uni-bayreuth.de