Heart diseases are a major socioeconomic burden. Despite considerable progress in the prevention and minimization of heart damage, the prevalence of heart insufficiency increases continuously. The aim of this subproject is the reproducible production of human cardiac substitute tissue based on a scaffold with adjustable mechanical properties from spider silk bioink and cardiac cells using 3D printing technology. The long-term goal is the treatment of heart diseases.
Roshanbinfar K, Vogt L, Greber B, Diecke S, Boccaccini A, Scheibel T, Engel FB. (2018) Electroconductive Biohybrid Hydrogel for Enhanced Maturation and Beating Properties of Engineered Cardiac Tissues, Adv Funct Mater, 2018 Sep 06. doi: 10.1002/adfm.201803951
Engel FB. (2018) New scaffolds for cardiac repair, ESC Congress 2018 (European Cardiac Society) 25 – August 2018 (Munich, Germany)