B03 | Simultaneous printing of Biofabricates and custom sized bioreactors

Due to the complexity of bioprinted constructs, the supply of the embedded cells with nutrients, as well as maturation of the construct to a functional tissue, tailored conditions must be maintained. The technological focus of TP B03 is on the integration of the bioprinting process in a functional bioreactor system where the bioconstruct and the bioreactor are printed simultaneously. By biofabrication of tissue models based on hydrogel composite materials and by generation of a suitable bioreactor platform, the feasibility of this concept will be shown. Furthermore, functional biofabrication of muscle tissue will demonstrate for the efficient generation of personalized specific 3D construct.

Prof. Dr. Aldo Boccaccini
Dr. Sahar Salehi
Dr. Jan Hansmann

Publications:

Steiner D, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier J, Horch RE, Arkudas A. (2018) Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds. Tissue Eng Part A. 2018 Mar 20. doi: 10.1089/ten.TEA.2017.0496.      Front Cover for Tissue Engineering Part A

Jobs:

PhD position in Project B03 available

 

Susanne Heid

Previous academic education: Bachelor of Science in Nanotechnology, Master of Science in Nanotechnology – passed with distinction: “Tissue Plasminogen Activator Functionalized Iron Oxide Nanoparticles for Targeted Fibrin Clot Dissolution”
Academic Advisor at SFB/TRR 225: Prof. Dr.-Ing. habil. Aldo R. Boccaccini, Dr. Rainer Detsch (technical advisor)
Location: Friedrich-Alexander University of Erlangen-Nuremberg, Institute of Biomaterials
Topic of thesis: Simultaneous printing of biofabricated constructs and bioreactors: composite bioinks and non-degradable polymers for regenerative approaches
Main techniques and methodologies to be used: Hard and soft printing, mechanical studies, rheology, spectroscopy, microscopy, cell culture

Contact: susanne.heid@fau.de

Marius Gensler

Previous academic education: Master (Biology)
Academic Advisor within SFB/TRR 225: Dr.-Ing. Jan Hansmann
Location: University of Würzburg, Department Tissue Engineering and Regenerative Medicine
Topic of thesis: Simultaneous printing of bioreactor and tissue (working title)
Main techniques and methodologies to be used: In Silico Simulations, Cell Culture, 3D Printing, Bioreactor Handling

Contact: marius.gensler@stud-mail.uni-wuerzburg.de

Previous academic education:
Academic Advisor within SFB/TRR 225: Dr. Sahar Salehi
Location: Bayreuth
Topic of thesis: Simultaneous printing of biofabricated constructs and bioreactors: composite bioinks for skeletal muscle tissue regeneration
Main techniques and methodologies to be used: Soft-printing, rheology, mechanical tests, spectroscopy, microscopy and cell culture.

Contact: