Due to the complexity of bioprinted constructs, the supply of the embedded cells with nutrients, as well as maturation of the construct to a functional tissue, tailored conditions must be maintained. The technological focus of TP B03 is on the integration of the bioprinting process in a functional bioreactor system where the bioconstruct and the bioreactor are printed simultaneously. By biofabrication of tissue models based on hydrogel composite materials and by generation of a suitable bioreactor platform, the feasibility of this concept will be shown. Furthermore, functional biofabrication of muscle tissue will demonstrate for the efficient generation of personalized specific 3D construct.
Previous academic education: Bachelor of Science in Nanotechnology, Master of Science in Nanotechnology – passed with distinction: “Tissue Plasminogen Activator Functionalized Iron Oxide Nanoparticles for Targeted Fibrin Clot Dissolution”
Academic Advisor at SFB/TRR 225: Prof. Dr.-Ing. habil. Aldo R. Boccaccini, Dr. Rainer Detsch (technical advisor)
Location: Friedrich-Alexander University of Erlangen-Nuremberg, Institute of Biomaterials
Topic of thesis: Simultaneous printing of biofabricated constructs and bioreactors: composite bioinks and non-degradable polymers for regenerative approaches
Main techniques and methodologies to be used: Hard and soft printing, mechanical studies, rheology, spectroscopy, microscopy, cell culture
Previous academic education: Master (Biology)
Academic Advisor within SFB/TRR 225: Dr.-Ing. Jan Hansmann
Location: University of Würzburg, Department Tissue Engineering and Regenerative Medicine
Topic of thesis: Simultaneous printing of bioreactor and tissue (working title)
Main techniques and methodologies to be used: In Silico Simulations, Cell Culture, 3D Printing, Bioreactor Handling
Previous academic education:
Academic Advisor within SFB/TRR 225: Dr. Sahar Salehi
Topic of thesis: Simultaneous printing of biofabricated constructs and bioreactors: composite bioinks for skeletal muscle tissue regeneration
Main techniques and methodologies to be used: Soft-printing, rheology, mechanical tests, spectroscopy, microscopy and cell culture.
Steiner D, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier J, Horch RE, Arkudas A. (2018) Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds. Tissue Eng Part A. 2018 Mar 20. doi: 10.1089/ten.TEA.2017.0496. Front Cover for Tissue Engineering Part A
Salehi S, Kharaziha M, Ionov L, Scheibel T. (2019) Composite ink development from bioceramic nanoparticles for bone tissue regeneration, 9th biennial Australian Colloid and Interface Symposium (ACIS) 3 – 7 February 2019 (Hobart, Tasmania, Australia)
Boccaccini A. (2018) Bioactive materials and biofabrication for tissue engineering: achievements and challenges”, Invited presentation at Polytechnic School (Escuela Politecnica Superior, EPS), University of Seville, 31st October 2018 (Seville, Spain).
Boccaccini A. (2018) Development of composite bioinks incorporating bioreactive inorganic particles, Invited presentation at: International Conference on Biofabrication (ISBF) 2018, 28-31 October 2018 (Würzburg, Germany).
Boccaccini A. (2018) Biofabrication with alginate di-aldehyde / gelatin (ADA/GEL) hydrogels: progress, applications and challenges, Oral presentation at: Biomaterials and Novel Technologies for Healthcare, 2nd International Biennial Conference BioMaH, Frascati, 8-11 October, 2018 (Rome, Italy).
Boccaccini A. (2018) Bioactive materials and biofabrication for tissue engineering applications. Invited seminar at: CONICET Laboratory of Integration of Cellular Signals at the Institute for Histology and Embryology, Faculty of Medicine, National University of Cuyo (UNCUYO), 27th August 2018 (Mendoza, Argentina).
Boccaccini A. (2018) Bioactive materials and biofabrication for bone and soft tissue engineering, Invited lecture at: Justus-Liebig-University Giessen, Medical School, 19th July 2018 (Giessen, Germany).
Boccaccini A. (2018) Bioactive materials and biofabrication for tissue engineering: progress and challenges. Invited speaker at: Junior EUROMAT 2018 Conference, 8-12 July 2018 (Budapest, Hungary).
Boccaccini A. (2018) Enhancing alginate based bioinks for biofabrication: the composites approach, Invited speaker at: 1st TERMIS-EU Workshop on “3D Printing in Musculoskeletal Tissue Engineering”, 22-23 March 2018 (Warsaw, Poland).
Boccaccini A. (2018) Bioactive materials and biofabrication approaches for hard tissue regeneration, Invited speaker at: 2nd Sino-German Symposium on Reconstruction and Repair of Musculoskeletal Tissues, Mainz University Medical Center, 13-14 March 2018 (Mainz, Germany).
Salehi S, Ionov L, Scheibel T (2018) Bioactive Composite Ink for Bone Tissue Regeneration, Annual Conference of the International Society for Biofabrication (ISBF), Würzburg, Germany, on 28 – 31 October, 2018.
Gensler M, Komma M, Salehi S, Detsch R, Boccaccini A, Hansmann J (2018) Optimized bioreactor concepts for simultaneous printing of bioreactor and tissue, Annual Conference of the International Society for Biofabrication (ISBF), Würzburg, Germany, on 28-31 October, 2018.