Due to the complexity of bioprinted constructs, the supply of the embedded cells with nutrients, as well as maturation of the construct to a functional tissue, tailored conditions must be maintained. The technological focus of TP B03 is on the integration of the bioprinting process in a functional bioreactor system where the bioconstruct and the bioreactor are printed simultaneously. By biofabrication of tissue models based on hydrogel composite materials and by generation of a suitable bioreactor platform, the feasibility of this concept will be shown. Furthermore, functional biofabrication of muscle tissue will demonstrate for the efficient generation of personalized specific 3D construct.
Steiner D, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier J, Horch RE, Arkudas A. (2018) Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds. Tissue Eng Part A. 2018 Mar 20. doi: 10.1089/ten.TEA.2017.0496. Front Cover for Tissue Engineering Part A