This project aims at developing a synthetic, cell-compatible and modular bioink-platform. Diblock copolymers based on poly(2-oxazoline)s will be deployed exhibiting suitable thermo- and shearresponsive behavior. This novel bioink platform will be modified by a dual-crosslinking mechanism to (i) guarantee mechanical stability after printing and (ii) to modulate the stiffness of the ink during cell-culture experiments.
Gutmann M, Braun A, Seibel J, Lühmann T. (2018) Bioorthogonal Modification of Cell Derived Matrices by Metabolic Glycoengineering. ACS Biomater. Sci. Eng. 2018 Mar 13, doi: 10.1021/acsbiomaterials.8b00264.
Lorson T, Jaksch S, Jüngst T, Groll J, Lühmann T, Luxenhofer R. (2018) Nanostructured, thermoresponsive and biocompatible hydrogels based on Poly(2-oxazoline)s for 3D bioprinting and biofabrication, Joint DIPC, JCNS & SoftComp Workshop 2018: Functional Polymers, 19 – 21 March 2018, San Sebastian, Spain
Lorson T, Jüngst T, Jaksch S, Lühmann S, Luxenhofer R. (2018) Biocompatible,Thermoresponsive, and Printable Poly(2-Oxazoline) Gels. Polymers: Design, Function and Application, Barcelona, 22–23 Mar 2018