A01 | Alginate based Hydrogels with adhesive functionalization and controlled degradation

The aim of subproject A01 is the systematic investigation and optimization of adhesive, microstructural as well as microscopic and macroscopic mechanical properties of biofabricated hierarchical tissue analogues based on alginate dialdehyde (ADA). This also includes optimizing the temporal degradation of the alginate matrix and its replacement by a cell-generated extracellular matrix. Our long-term goal is to achieve tight control over the temporal changes in adhesive, mechanical and structural properties and the associated cell-biological behavior in alginate-based biofabricated tissues.

Prof. Dr. Aldo Boccaccini
Prof. Dr. Ben Fabry

Publications:

Rottensteiner-Brandl U, Detsch R, Sarker B, Lingens L, Köhn K, Kneser U, Bosserhoff AK, Horch RE, Boccaccini AR, Arkudas A. (2018) Encapsulation of Rat Bone Marrow Derived Mesenchymal Stem Cells in Alginate Dialdehyde/Gelatin Microbeads with and without Nanoscaled Bioactive Glass for In Vivo Bone Tissue Engineering. Materials (Basel). 2018 Oct 1;11(10). pii: E1880. doi: 10.3390/ma11101880.

Steiner D, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier J, Horch RE, Arkudas A. (2018) Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds. Tissue Eng Part A. 2018 Mar 20. doi: 10.1089/ten.TEA.2017.0496.      Front Cover for Tissue Engineering Part A

Jobs:

PhD position in Project A01 available

Jonas Hazur

Previous academic education: Sc. in Nanotechnology, Sc. in Materials Science: “Characterization of rheological behavior and processability in additive manufacturing of different medical grade alginate gel systems“
Academic Advisor within SFB TRR225: Prof. Dr.-Ing. habil. Aldo R. Boccaccini, Dr.-Ing. Rainer Detsch (technical advisor)
Location: Friedrich-Alexander University of Erlangen-Nuremberg, Institute of Biomaterials
Topic of thesis: Systematical investigation of adhesive functionalized and controlled degrading alginate based hydrogels
Main techniques and methodologies to be used: Bioplotting, chemical and physical modification, cell culture, degradation studies, spectroscopy, microscopy, rheology

Contact: Jonas.hazur@fau.de

Sebastian Richter

Previous academic education: Dipl. Ing.
Academic Advisor within SFB TRR225: Prof. Dr. Ben Fabry
Location: Friedrich-Alexander University of Erlangen-Nuremberg, LS f Biophysik
Topic of thesis:
Main techniques and methodologies to be used: Software- & Hardware-Development / Mashine Learning / Computer Vision

Contact: srichter@biomed.uni-erlangen.de