A01 | Alginate based Hydrogels with adhesive functionalization and controlled degradation

The aim of subproject A01 is the systematic investigation and optimization of adhesive, microstructural as well as microscopic and macroscopic mechanical properties of biofabricated hierarchical tissue analogues based on alginate dialdehyde (ADA). This also includes optimizing the temporal degradation of the alginate matrix and its replacement by a cell-generated extracellular matrix. Our long-term goal is to achieve tight control over the temporal changes in adhesive, mechanical and structural properties and the associated cell-biological behavior in alginate-based biofabricated tissues.

Prof. Dr. Aldo Boccaccini
Prof. Dr. Ben Fabry

Jobs:

PhD position in Project A01 available

Jonas Hazur

Previous academic education: Sc. in Nanotechnology, Sc. in Materials Science: “Characterization of rheological behavior and processability in additive manufacturing of different medical grade alginate gel systems“
Academic Advisor within SFB TRR225: Prof. Dr.-Ing. habil. Aldo R. Boccaccini, Dr.-Ing. Rainer Detsch (technical advisor)
Location: Friedrich-Alexander University of Erlangen-Nuremberg, Institute of Biomaterials
Topic of thesis: Systematical investigation of adhesive functionalized and controlled degrading alginate based hydrogels
Main techniques and methodologies to be used: Bioplotting, chemical and physical modification, cell culture, degradation studies, spectroscopy, microscopy, rheology

Contact: Jonas.hazur@fau.de

Sebastian Richter

Previous academic education: Dipl. Ing.
Academic Advisor within SFB TRR225: Prof. Dr. Ben Fabry
Location: Friedrich-Alexander University of Erlangen-Nuremberg, LS f Biophysik
Topic of thesis:
Main techniques and methodologies to be used: Software- & Hardware-Development / Mashine Learning / Computer Vision

Contact: srichter@biomed.uni-erlangen.de

Presentations:

Boccaccini AR (2018) Bioactive materials and biofabrication for tissue engineering: achievements and challenges”, Invited presentation at Polytechnic School (Escuela Politecnica Superior, EPS), University of Seville, 31st October 2018 (Seville, Spain).

Boccaccini AR (2018) Development of composite bioinks incorporating bioreactive inorganic particles, Invited presentation at: International Conference on Biofabrication (ISBF) 2018, 28-31 October 2018 (Würzburg, Germany).

Boccaccini AR (2018) Biofabrication with alginate di-aldehyde / gelatin (ADA/GEL) hydrogels: progress, applications and challenges, Oral presentation at: Biomaterials and Novel Technologies for Healthcare, 2nd International Biennial Conference BioMaH, Frascati, 8-11 October, 2018 (Rome, Italy).

Boccaccini AR (2018) Bioactive materials and biofabrication for tissue engineering applications. Invited seminar at: CONICET Laboratory of Integration of Cellular Signals at the Institute for Histology and Embryology, Faculty of Medicine, National University of Cuyo (UNCUYO), 27th August 2018 (Mendoza, Argentina).

Boccaccini AR (2018) Bioactive materials and biofabrication for bone and soft tissue engineering, Invited lecture at: Justus-Liebig-University Giessen, Medical School, 19th July 2018 (Giessen, Germany).

Boccaccini AR (2018) Bioactive materials and biofabrication for tissue engineering: progress and challenges. Invited speaker at: Junior EUROMAT 2018 Conference, 8-12 July 2018 (Budapest, Hungary).

Boccaccini AR (2018) Enhancing alginate based bioinks for biofabrication: the composites approach, Invited speaker at: 1st TERMIS-EU Workshop on “3D Printing in Musculoskeletal Tissue Engineering”, 22-23 March 2018 (Warsaw, Poland).

Boccaccini AR (2018) Bioactive materials and biofabrication approaches for hard tissue regeneration, Invited speaker at: 2nd Sino-German Symposium on Reconstruction and Repair of Musculoskeletal Tissues, Mainz University Medical Center, 13-14 March 2018 (Mainz, Germany).