The aim of subproject A01 is the systematic investigation and optimization of adhesive, microstructural as well as microscopic and macroscopic mechanical properties of biofabricated hierarchical tissue analogues based on alginate dialdehyde (ADA). This also includes optimizing the temporal degradation of the alginate matrix and its replacement by a cell-generated extracellular matrix. Our long-term goal is to achieve tight control over the temporal changes in adhesive, mechanical and structural properties and the associated cell-biological behavior in alginate-based biofabricated tissues.
Rottensteiner-Brandl U, Detsch R, Sarker B, Lingens L, Köhn K, Kneser U, Bosserhoff AK, Horch RE, Boccaccini AR, Arkudas A. (2018) Encapsulation of Rat Bone Marrow Derived Mesenchymal Stem Cells in Alginate Dialdehyde/Gelatin Microbeads with and without Nanoscaled Bioactive Glass for In Vivo Bone Tissue Engineering. Materials (Basel). 2018 Oct 1;11(10). pii: E1880. doi: 10.3390/ma11101880.
Steiner D, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier J, Horch RE, Arkudas A. (2018) Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds. Tissue Eng Part A. 2018 Mar 20. doi: 10.1089/ten.TEA.2017.0496. Front Cover for Tissue Engineering Part A