Open PhD positions

We seek highly motivated PhD canditates who enjoy shaping the field of biofabrication in an interdisciplinary way in a large and successful team. Biologists, chemists, engineers, biochemists, physicists and material scientists are welcome to check the following subprojects and contact responsive PI´s.

For further information, please contact the scientific coordinator Dr. Jennifer Ritzer (ritzer_j@ukw.de).

A02: Hyaluronic acid (HA) represents a major component of the human extracellular matrix, however, so far highly versatile HA-based materials for biofabrication are lacking. The overall aim of this project is to develop a HA-based bioink platform utilizing multi-functional crosslinkers (PEG, modified biopolymers) that enables the controlled differentiation of mesenchymal stem cells. The modification with peptides and growth factors as well as the processing into gradient materials will further promote the development of coherent tissues within the printed 3D constructs. For the long term, this work aims to generate bioinks for the development of clinically relevant tissue models

We are looking for an excellent, highly motivated earlycareer researcher to join our research team. The ideal candidate should have a Master‘s Degree in one of Chemistry or Pharmacy. Basic knowledge in polymer chemistry is beneficial.
Fluency in German or English is expected.

Supervisor: Dr. habil. Jörg Teßmar (http://trr225biofab.de/de/project-a02/)

Please find additional information here: PhD_position_neue Förderperiode_FMZ

A06: Erzeugung von zellbeladenen Mikrogelen und Etablierung als Additive in Biotinten, als mechanischer Schutz vor Scherkräften während des Druckens und zur Erweiterung des Biofabrikationsfensters in Richtung von Biotinten mit höherer Viskosität und höheren Scherkräften. Biochemische Funktionalisierung und Anpassung der Abbaubarkeit der Mikrogele, um die Mikroumgebung der eingekapselten Zellen zu verändern und ihr Verhalten zu steuern. Etablieren des gleichzeitigen Druckens verschiedener Zelltypen durch Suspensionen von zellbeladenen Mikrogelen als Biotinte.

Betreuer: Dr. Jürgen Groll (http://trr225biofab.de/project-a06/)

Weitere Informationen finden Sie hier: PhD_position_neue Förderperiode_FMZ

A08: The aim of this project is the fabrication of hierarchically structured tissues with integrated fiber-based structures, which give the matrix anisotropic properties for directed cell growth, as well as tubular elements for the supply of nutrients and oxygen. To implement the project, various manufacturing methods such as 4D biofabrication approaches and established 3D printing and fiber spinning processes will be combined. The integrated tubular structures should also provide a basis for a later vascularization of the constructs after tissue maturation.

Betreuer: Prof. Dr. Leonid Ionov

Please find additional information here: Ionov_A PhD position in Biofabrication

B02: The aim of this project is biofabrication of perfusable and endothelialized microvascular networks, which will be produced by MEW of sacrificial thermoresponsive polyoxazolines. Particular focus will be placed on adapting the network geometry and the surrounding cell-containing hydrogels to tissue-specific requirements of B and C projects and to the design of appropriate microscopy-compliant bioreactors. Besides, extensive investigations of endothelial function in the fabricated tissue models are planned, including angiogenesis, interactions with circulating cells, barrier function and regulation of physiological processes in the hydrogel-contained cells.

PI: Prof. Dr. Jürgen Groll Please find additional information here: PhD_position_neue Förderperiode_FMZ

PI: Prof. Iwona Cicha Please find additional information here: PhD student job description_B02_Cicha

B03: The aim of subproject B03 is the development of different composite bioinks with ion-releasing (bioreactive) particles and electrically conductive fillers for the bioprinting of skeletal muscle tissue. Basically, synergistic stimulation of cells and cell growth through electrical and biochemical factors for the formation of highly mature muscle tissue will be investigated in vitro. For this purpose, a bioreactor with complex structure and functionalities will be designed and fabricated using additive manufacturing, which will be tissue-specific and will enable the electromechanical stimulation of skeletal muscle tissue.

The projects aim to solve a longstanding challenge in the field of skeletal muscle tissue engineering, bioprinting, and the development of functional tissue models. The project is highly interdisciplinary and requires collaboration with researchers from engineering, medicine, and chemistry. The applicationoriented research will be performed in laboratories located at the Department of Biomaterials in both universities of Bayreuth and Erlangen and Chair of Manufacturing and  Remanufacturing Technology of the University of Bayreuth.

We are looking for an excellent, highly motivated earlycareer researcher to join our research team. The ideal candidate should have a Master‘s Degree in one of Materials Engineering, Chemistry, Biomedical Engineering, Polymer, or Biology. Basic knowledge in cell culture and polymer chemistry is beneficial. Experience in hydrogel preparation and physical and mechanical properties characterization, cell culture experiments, and analysis with different assays are most welcome.
Fluency in German or English is expected.

Supervisor: Dr. Sahar Salehi (http://trr225biofab.de/project-B03/)

Find additional information here: Phd position 2022_Sahar_Salehi

B04: Biofabrikation von künstlichen Gefäßstrukturen mit korrekter hierarchischer Organisation und Wandmorphologie, bestehend aus Intima, Media und Adventitia, durch die Ausnutzung der zellulären Plastizität von Gefäßwand-Stammzellen (VW-SCs). Durch das Drucken von mit VW-SC beladenen Biotinten in selbstheilende Stützgele, die Verwendung von gefäßwandspezifischen Matrixkomponenten und die Perfusion der Strukturen wollen wir mittel- bis langfristig komplexe und hierarchisch organisierte Gefäßstrukturen biofabrizieren.

Betreuer: Prof. Dr. Jürgen Groll (http://trr225biofab.de/project-b04/)

Weitere Informationen finden Sie hier: PhD_position_neue Förderperiode_FMZ

B05: Die Interaktion von Zellen mit Biotinten, sowie die direkte Zell-Zell Interaktion, ist essenziell für die Biofabrikation von Gewebekonstrukten. Dieses Projekt zielt darauf ab, durch Zelloberflächenmodifikationen mittels Membran-Engineering den während des Druckprozesses entstehenden Scherstress zu verringern, die Proliferation der Zellen im Hydrogel zu steigern, eine Zell-Zell Aggregation und Sphäroidbildung zu beeinflussen und die Interaktion der Zellen mit der Biotinte durch Kopplung eines spezifischen Galectin-1 Liganden zu optimieren. Langfristiges Ziel ist es, durch Membran-Engineering Zellen und Biotinten so zu modifizieren, dass das Postfabrikationsverhalten von Zellen in biofabrizierten Konstrukten optimiert wird.

Wir suchen eine/n hochmotivierte/n Kandidatin/Kandidaten mit einem

  • abgeschlossenen Master-Studium Biochemie / Biologie / Biotechnologie / Chemie / Funktionswerkstoffe / Materialwissenschaften / Biofabrikation oder einer verwandten Disziplin
  • hohen Maß an Teamgeist und der Fähigkeit zu selbstständiger Arbeit und interdisziplinärer Zusammenarbeit
  • großes Interesse an biologischen Prozessen

Betreuer: Prof. Dr. Regina Ebert (http://trr225biofab.de/project-b05/)

Weitere Informationen finden Sie hier: Stellenausschreibung SFB 2.FP_B05_Regina_Ebert

C06: Generierung eines ein 3D ex vivo Modells des Glomerulus durch Kombination von top-down Fabrikationsmethoden und bottom-up Strategien. Strukturelle Nachahmung der Geometrie des Glomerulus durch gezielten Einbau von mesangialen Sphäroiden zwischen Kapillarschlingen, bestehend aus Endothelzellen, artifizieller Basalmembran und Podozyten (Bioassembly), um den Effekt der 3D-Struktur auf die Selbstorganisation, Reifung, parakrine Zellinteraktion und Bildung extrazellulärer Matrix zu untersuchen.

Betreuer: Dr. Taufiq Ahmad

Weitere Informationen finden Sie hier: PhD_position_neue Förderperiode_FMZ

PhD positions

We seek highly motivated PhD canditates who enjoy shaping the field of biofabrication in an interdisciplinary way in a large and successful team. Biologists, chemists, engineers, biochemists, physicists and material scientists are welcome to check our involved subprojects and contact responive PI´s.

For further information, please contact the scientific coordinator Dr. Jennifer Ritzer (ritzer_j@ukw.de).

We are specifically welcoming intelligent, highly motivated, and creative students for a bachelor and master thesis as well as student assistents in our research assocition. Also motivated medical students are highly welcome to join the SFB/TRR 225 for a medical dissertation (Dr. med.).

Interested candidates are invited to contact the project office (trr225@fmz.uni-wuerzburg.de) or the project leader of the projects of interest by email for more information.

An application should include the curriculum vitae, motivation letter and academic certificates.